Sickle Cell Disease, Acute Chest Syndrome

KEY FACTS Terminology New pulmonary opacity on chest radiograph + ≥ 1 additional symptom (such as fever, cough, sputum production, tachypnea, dyspnea, or hypoxia) in setting of sickle cell disease (SCD) Imaging Upper & middle lobe opacities more common in children Lower lobe disease more common in adults Initial chest radiograph may be normal (46%) Opacity may not appear until 2-3 days after symptoms develop Opacities…