Category Pathology

Clear cell renal cell carcinoma

Definition The most common histological subtype of renal cell carcinoma (RCC), composed of cells with clear or eosinophilic cytoplasm and a prominent but delicate vascular network Clinical features Epidemiology Two percent of all malignancies and approximately 70% of RCCs Primarily…

Renal oncocytoma

Definition Benign renal epithelial neoplasm composed of large round-to-polygonal cells with abundant mitochondria-rich eosinophilic cytoplasm Clinical features Epidemiology 4%–8% of adult renal epithelial neoplasms in surgical pathology Wide range of age distribution with a peak incidence in the seventh decade…

Papillary adenoma

Definition Epithelial tumor with tubulopapillary architecture, low nuclear grade, and a diameter of 15 mm or less Clinical features Epidemiology Increased incidence with age No gender predilection You’re Reading a Preview Become a Clinical Tree membership for Full access and…

Infectious interstitial nephritis

Definition Chronic infection of the renal parenchyma by a specific infectious agent Clinical features Epidemiology Uncommon, but more frequent in immunocompromised patients and transplant recipients. Common bacteria and fungi are the most frequent causative agents during the early post-transplantation period.…

Acute interstitial nephritis

Definition A clinicopathological entity characterized by inflammation in the renal interstitium with various etiologies, often secondary to an allergic reaction to a drug Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited…

Acute kidney injury (acute tubular necrosis)

Definition A clinicopathological entity with pathological changes in the renal tubules when ischemic or toxic injuries affect the kidney Clinical features Epidemiology Acute kidney injury (AKI) is the most common cause of acute renal failure. The precipitating events include ischemic…

Malignant nephrosclerosis

Definition A clinicopathological syndrome characterized by a thrombotic microangiopathy induced by severe hypertension (systolic pressure greater than 220 mm Hg or diastolic pressure greater than 120 mm Hg) Clinical features Epidemiology The average age at diagnosis is 40 years, and…

Benign nephrosclerosis

Definition Pathological changes in the kidney induced by chronic mild to moderate hypertension Clinical features Epidemiology Hypertension affects 20%–40% of the population in Western society. Vascular diseases of the kidneys can be both a cause and a consequence of hypertension.…

Renal papillary necrosis

Definition Coagulative necrosis involving the papillae of the renal medulla, classically associated with a number of underlying conditions, all of which predispose the patient to renal medullary ischemia Clinical features You’re Reading a Preview Become a Clinical Tree membership for…