Definition An autosomal dominant disease caused by germline mutations in the von Hippel-Lindau ( VHL ) tumor suppressor gene on 3p25.3 and characterized by a constellation of tumors including renal cysts and clear cell renal cell carcinoma Clinical features Epidemiology…
You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
Definition A group of renal cell carcinomas (RCCs) whose morphology or growth pattern does not readily fit any of the RCC subtypes recognized by the current World Health Organization classification Clinical features Epidemiology Represents 3%–5% of all RCCs The incidence…
Definition Sarcomatoid component present in renal cell carcinoma (RCC) of any histologic subtype Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in…
Definition A group of recently described renal cell carcinomas with morphology similar to tumors in patients with tuberous sclerosis complex (TSC) and harboring somatic mutations in the genes of the TSC and mTORC1 pathways. They may have diverse morphological patterns.…
Definition A recently described variant of renal cell carcinoma (RCC) defined morphologically by solid and cystic areas composed of tumor cells with voluminous eosinophilic cytoplasm and basophilic coarse cytoplasmic granules and positive cytokeratin 20 staining Clinical features Epidemiology Incidence currently…
Definition A group of renal cell carcinoma (RCC) with prominent smooth muscle–rich stroma that invests tumor cells, probably a heterogeneous group of RCCs with similar morphology. Considered an emerging/provisional entity in the World Health Organization (WHO) classification Clinical features Epidemiology…
Definition An indolent variant of renal cell neoplasm consists of tubular and papillary structures lined by bland clear cells with a distinct immunophenotype Clinical features Epidemiology Accounts for 1%–4% of all renal tumors Mean patient age, 60 years (range, 18–88…
Definition A recently described, rare variant of renal cell carcinoma (RCC) with a morphology that closely mimics well-differentiated thyroid follicular neoplasms Also termed thyroid-like follicular carcinoma of the kidney or thyroid follicular carcinoma-like renal cell carcinoma Clinical features Epidemiology Rare,…