Definition A destructive granulomatous inflammatory process of renal parenchyma as the result of long-term urinary tract obstruction and infection Clinical features Epidemiology Seventy percent of patients are female. Ages range widely, from newborn to elderly. Urine cultures most frequently show…
Definition Pathologic changes secondary to chronic obstruction of the urinary outflow Clinical features Epidemiology Obstruction is more common in males during childhood (ureteropelvic obstruction, posterior urethral valves, and other congenital anomalies), in females during adulthood (gynecologic diseases), and in males…
Definition Pathological changes observed in the kidney as the result of vesicoureteral reflux (VUR), intrarenal reflux, and repeated UTIs; also termed reflux nephropathy Clinical features Epidemiology VUR occurs in approximately 1% of children and is found in 30%–50% of children…
Definition Acute suppurative inflammation of the kidney caused by bacterial infection, due most commonly to ascent from a lower urinary tract infection and less commonly to hematogenous spread in septic patients Clinical features Epidemiology Common, with 15–17 cases annually per…
Definition An acquired cystic lesion with fluid collection in the kidney; may originate from diverticula of the distal renal tubules or collecting ducts. Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited…
Definition Development of bilateral and multiple renal cysts in patients whose chronic renal failure cannot be attributed to a hereditary etiology Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become…
Definition Cystic dilatation of papillary collecting ducts of one or more renal pyramids Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in…
Definition A late-onset, autosomal dominant disorder characterized by the progressive development of innumerable cysts in the kidney, leading to renal insufficiency. Associated with mutations in the PKD1 gene on chromosome 16 (16q13.3) in 85% of patients, or the PKD2 gene…
Definition Rare, early onset, autosomal recessive inherited polycystic kidney disease Associated with single gene ( PKHD1 ) mutation on chromosome 6p21–23 PKHD1 gene encodes polyductin/fibrocystin Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and…
Definition Localized cystic disease (LCD) involves part of a, or rarely entire, kidney with multiple cysts surrounded by normal renal parenchyma. Also known as unilateral cystic disease or segmental cystic disease. Clinical features Epidemiology Rare Median age 33.3 (range 18–56)…