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Acknowledgment I wish to thank Dr. Ian Yuan for his work on this chapter in the earlier edition of this book. Risk Affects 2–4% of population; equal occurrence by gender; highest in 25–44 y. Lifetime risk 10–25% for women and…

Risk Risk factors for the development of POD can be categorized as pt or procedure related. Pt-related factors: Age >75 y. Preexisting cognitive dysfunction or depression. Male sex. Preexisting severe illness. Polypharmacy (>3 medications) and use of psychoactive medications. History…

Risk Risk factors determined by spinal level Cervical spine: C3 and C4 most common; 10% of degenerative disk disease Thoracic: uncommon; can be related to trauma or tumor; 0.2–1.8% of disk disease Lumbar; very common; 85–90% of disk disease; third…

Risk Incidence in USA: 170,000–200,000 new cases; 90,000–100,000 recurrent cases. VTE is the third most frequent acute cardiovascular syndrome after MI and CVA. Half of all episodes are associated with recent surgery or hospitalization. VTE is recognized as the leading…

Risk For live births: 1:10,000; equal male to female prevalence Associated with younger maternal age May not be identified until later in life Perioperative Risks Reduced cortisol stress response in undiagnosed or untreated pts. Hormone tests may be normal in…

Risk Multiple genetic factors; mostly sporadic with limited familial inheritance Range: 1:10,000-30,000 newborns Perioperative Risks Variable phenotypic expression and organ involvement Increased incidence of additional developmental abnormalities Depend upon severity of disease and comorbidities, which may include elevated ICP; craniofacial,…

Risk Seroprevalence increases with age and low socioeconomic status in USA: From 58.9% in those aged ≥6 y to 90.8% in those ≥80 y. Also higher in non-Hispanic blacks, Mexican Americans, and women. Severe disease from CMV is rare in…

Acknowledgment The authors wish to acknowledge the contributions to the previous edition of this chapter by Daniel Roke and John Algren. Risk Prevalence ranges from 1:2500 births in white population to 1:17,000 in African Americans; prevalence growing faster than incidence…

Risk Potent rapid-onset toxin, especially with inhalation of HCN (volatile liquid). May be absorbed through mucous membranes; CN ingestion results in slower onset. Diffuses rapidly through body with high intracellular fixation to cytochrome aa 3 in cellular mitochondria to paralyze…

Risk Onset generally occurs in third and fourth decades. Approximately 3–5 times more common in women than men. 5-y mortality rate from adrenal carcinomas has been estimated to be >70%. Perioperative Risks Lyte abnormalities Consequences of untreated Htn Hyperglycemia Cardiovascular…