Risk 1:4000 births with variable penetrance Worry About Cardiac anomalies Immunodeficiency and poor wound healing Palatal anomalies Hypocalcemia Seizures Difficult mask/intubation Overview Chromosome deletion 22q11.2. Classic triad: Conotruncal cardiac anomalies, hypoplastic thymus, and hypocalcemia. Clinical phenotype varies with mild-to-severe forms…
Risk Incidence in USA: 200–300 million new cases/y of acute, with >900,000 hospital admissions Chronic: 1–5% of population; increasing with age; female at greater risk than male Acute: Male and female equivalent Perioperative Risks Hypovolemia with hemodynamic instability Electrolyte abnormalities,…
Risk Occurs in approximately 1 in 2500–5000 births; 12–25% have associated anomalies, in particular cardiac (20%), chromosomal (5–16%), and neurologic. Parents who have one child with isolated defect have 2% chance with next child. Usually left sided (90%) due to…
Risk Typically seen in pts with type I diabetes mellitus; can occur in pts with ketosis-prone type II diabetes. Stress related to acute infection, trauma, surgery, MI, pulm embolism, pancreatitis, alcohol abuse, stroke, emotional trauma, or drugs (steroids, thiazides, sodium-glucose…
Risk Hereditary/familial (rare): Nephrogenic DI due to mutations in the AVP receptor gene, with X-linked recessive transmission; or AQP2, usually with autosomal recessive transmission, but autosomal dominant transmission also occurs; overall, males at greater risk than females Central (hypothalamic) DI…
Risk Incidence of GDM approximately 5–6% of all pregnancies. Increased in African American, Hispanic, Asian, Native American, or Pacific Islander women. Risk factors: Maternal age >25 y. Previous delivery of macrosomic infant. Glucosuria. History of polycystic ovarian syndrome. Previous unexplained…
Risk Incidence in USA more than 25 million Highest prevalence: Hispanics and Native Americans Gender predominance: None Metabolic syndrome associated with obesity and sedentary lifestyle Perioperative Risks Increased risk 5–10 times if end-stage renal disease, CV, CHF, or autonomic neuropathy;…
Risk Incidence in USA: 1.25 million. Perioperative Risks Risk of requiring a CABG is increased 5–10 times in presence of ESRD, CHF, or autonomic neuropathy; without these conditions, the risk is 1-1½ times that of a normal person. Worry About…
Risk Birth prevalence of approximately 1:10,000; equal sex distribution 25% have PCD, an autosomal recessive disorder Perioperative Risks Increased risk of cardiac decompensation, pulm Htn, resp failure, airway obstruction, sepsis, raised intracranial pressure, and death Increased likelihood of emergent open-heart…
Risk Prevalence in USA: 3000–10,000. Group, demographics with highest prevalence include females, 2:1 relative to men, with a peak onset between 30–60 y of age. Perioperative Risks Increased risk of respiratory failure and infections postop Worry About Most case reports…