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Risk Within USA, approximately 4000 persons are affected (20% of all hemophiliacs): incidence: 1:25,000–30,000 males; 75–100 are people born with the disease in USA each year. No racial prevalence. Highest prevalence overwhelmingly in males. Perioperative Risks Increased risk of hemorrhagic…

Risk 1 per 800 live births Frequently associated with cleft lip Gender predominance: Cleft lip/palate more common in males (2:1); isolated cleft palate more common in females (3:1) Perioperative Risks Morbidity and mortality extremely low; only five life-threatening cases of…

Risk In USA, approximately 21% of adults smoke tobacco; prevalence varies inversely with socioeconomic class; men > women (26% vs. 15%). Minorities more likely to smoke and less likely to quit. Prevalence among adults and teens declining, but growing evidence…

Risk Smoking is the most common cause of preventable death. Half of cigarette smokers die of a smoking-related disease; on average, smokers lose at least 10 y of life expectancy. In USA, incidence of smoking is 17.8%: 42.1 million smokers…

Risk Rare: 2–5 new cases/million/y Average age of onset: 35–50 y Male = female Perioperative Risks Necrotizing eosinophilic vasculitis involving respiratory (100% of pts), cardiac (30–60% of pts), neurologic, GI, renal, and integumentary systems Worry About Respiratory complications from severe…

Risk 1:1000 live births Increased use of MRI leading to greater diagnosis Chiari malformation types I and II: Most common pediatric hindbrain abnormality Chiari type II always accompanied by myelomeningocele (which occurs in 0.6 of 1000 live births) Perioperative Risks…

Risk >250 cases in world literature Cherubs have a 40% chance of having a cherub offspring Perioperative Risks Swelling of lower face causing airway obstruction Displacement of ocular orbit and lower eyelid, causing visual changes Excessive blood loss from curettage…

Risk Newborns: 1 in 10,000 Perioperative Risks Respiratory failure in the neonate (due to choanal atresia) Difficult airway (cleft lip and palate and tracheomalacia) Aspiration risk Congenital heart disease Worry About If pt has respiratory insufficiency, consider subglottic stenosis. Postop…

Risk Incidence: 1:2500 people Peripheral disease severity varying from mild to severe autonomic, motor and sensory neuropathy Perioperative Risks Potential for postop weakness, especially following nondepolarizing neuromuscular blocking agents Worry About Resp insufficiency secondary to diaphragmatic or phrenic nerve dysfunction…

Risk 16–18 million people infected worldwide Rare in southern USA; chronic disease more likely in immigrants from endemic regions (South America, central Brazil prevalence 6–8%) More than 50,000 die each year; mortality estimated at 50% at 4 y secondary to…