D efinition —An infection of the mature ectocervical and/or metaplastic cervical transformation zone epithelium by human papillomavirus (HPV). Clinical Features Epidemiology Most commonly seen in sexually active, reproductive-age women. Can be diagnosed in any age group. Flat low-grade squamous intraepithelial…
D efinition and T erminology An exophytic cervical condyloma represents an infection of the mature ectocervical or metaplastic cervical transformation zone epithelium by human papillomavirus (HPV) type 6 or 11 (low–cancer-risk subtypes). The most appropriate term is low-grade squamous intraepithelial…
D efinition —A malignancy of skeletal muscle presenting as a polypoid vaginal mass in young girls. Clinical Features Epidemiology Uncommon. Usually seen in females under the age of 5 years. You’re Reading a Preview Become a Clinical Tree membership for…
PITFALL D efinition —A benign vaginal tumor composed of keratin-positive stromal cells. Clinical Features Epidemiology Uncommon. Seen in a wide age range (20 to 80 years), with a mean age of 40 years. You’re Reading a Preview Become a Clinical…
PITFALL D efinition —A very aggressive malignant tumor of dermal melanocytes arising in the vagina. Clinical Features Epidemiology Uncommon but not rare. Typically seen in postmenopausal women. May be more common in patients with a BRCA2 mutation. You’re Reading a…
D efinition —Epithelial malignancies that metastasize to the vagina. Clinical Features Epidemiology Patients with a primary carcinoma of another site. The vast majority are of endometrial origin. Over 90% of adenocarcinomas identified in the vagina are metastatic. You’re Reading a…
D efinition —An uncommon primary adenocarcinoma of the vagina, associated with in utero exposure to synthetic estrogen. Clinical Features Epidemiology Rare, except in women who were exposed to diethylstilbestrol (DES) in utero. The risk in DES-exposed women is estimated to…
D efinition —A malignant neoplasm of the vagina comprised of squamous epithelial cells with prominent papillary architecture. Clinical Features Epidemiology Associated with high-risk human papillomavirus (HPV) infection and may follow preexisting cervical intraepithelial or invasive neoplasia. Usually older women, in…
D efinition —Iatrogenically induced atrophic changes seen in the vaginal mucosa following radiation therapy. Clinical Features Epidemiology Common occurrence following radiation therapy. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership…
D efinition —Human papillomavirus (HPV)–related proliferation of the vaginal mucosa that leads to extensive, full-thickness loss of maturation of the vaginal epithelium. Clinical Features Epidemiology Patients present at a slightly older age than those with cervical dysplasia, with the majority…