D efinition — Early-stage invasive endocervical adenocarcinoma. Clinical Features Epidemiology Average age at diagnosis is early 40s. Human papillomavirus (HPV) associated. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If…
D efinition — A well-differentiated adenocarcinoma with a major exophytic and villoglandular component. Clinical Features Epidemiology Wide age range (third to seventh decades) with a mean age of 38 years. Human papillomavirus (HPV) associated. You’re Reading a Preview Become a…
D efinition — Changes seen in the cervical-vaginal epithelium following radiation therapy. Clinical Features Epidemiology A common finding in tissue samples following radiation therapy to the genital area. You’re Reading a Preview Become a Clinical Tree membership for Full access…
D efinition — A multinucleated endocervical cell atypia commonly associated with chronic inflammation. Clinical Features Epidemiology Relatively common, occasionally pronounced. Typically reproductive age, but can occur at any age. You’re Reading a Preview Become a Clinical Tree membership for Full…
D efinition — Hormonally driven benign morphologic alteration of the endocervical epithelium, most commonly associated with pregnancy or the recent postpartum state. Clinical Features Epidemiology Endocervical Arias-Stella effect may be seen in up to 50% of extensively examined gravid cervices.…
D efinition — Ectopic endometrial glands and stroma (endometriosis) or endometrial stroma in isolation (stromatosis). Clinical Features Epidemiology Endometriosis is common. Seen across all ages and demographic groups. Often follows punch or cone biopsy presumably because endometrial tissue colonizes the…
D efinition — A stratified mucin-producing intraepithelial lesion with prominent columnar cell differentiation (also called stratified adenocarcinoma in situ [AIS]). Clinical Features Epidemiology Young women, most ranging in age from 20 to 40 years. High-risk human papillomavirus (HPV) associated. You’re…
D efinition — Precursor lesion to invasive endocervical adenocarcinoma. Clinical Features Epidemiology Average age at diagnosis is 38 years. Human papillomavirus (HPV) related (>90%), especially types 16 and 18 in roughly equal proportion. About half of cases have a concurrent…
D efinition — A subtle pattern of endocervical adenocarcinoma in situ (AIS) which is frequently mistaken for reactive epithelial change. Clinical Features Epidemiology Young women; mean age at diagnosis is early 20s. Human papillomavirus (HPV) associated. You’re Reading a Preview…
D efinition — A poorly differentiated nonkeratinizing squamous carcinoma with prominent lymphocytic infiltrates. Clinical Features Epidemiology A malignant cervical neoplasm. Most prevalent in the fourth to sixth decades of life. Human papillomavirus (HPV) testing of a few cases has been…