D efinition —A specific pattern of invasive carcinoma that either mimics crypt involvement or combines crypt involvement with invasion, thus mimicking noninvasive carcinoma. Clinical Features Epidemiology The same as conventional invasive squamous carcinoma. You’re Reading a Preview Become a Clinical…
D efinition —A malignant neoplasm of the cervix comprised of squamous epithelial cells. Variants include large-cell keratinizing, large-cell nonkeratinizing, and small-cell nonkeratinizing squamous cell carcinoma (SCC), as well as papillary SCC. Clinical Features Epidemiology Associated with high-risk human papillomavirus (HPV)…
D efinition —Early invasive squamous cell carcinoma (SCC) measuring no more than 3 mm in depth in the biopsy or conization specimen. Clinical Features Epidemiology Associated with high-risk human papillomavirus (HPV) infection and preexisting cervical intraepithelial neoplasia. Will be found in…
D efinition —A squamous intraepithelial lesion not amenable to precise grading (QSIL) that demonstrates features seen in both low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion (HSIL). Clinical Features Epidemiology Typically encountered in reproductive-age women with atypical squamous…
D efinition —Immature metaplastic or reserve cell proliferations with mild atypia and strong p16 immunostaining. Clinical Features Epidemiology Reproductive-age women. Inconsistent human papillomavirus (HPV) association. Typically present with atypical squamous cells of undetermined significance (ASCUS) cervical smear. You’re Reading a…
D efinition —Any one of the spectrum of alterations within the cervical epithelium of postmenopausal women, including squamous intraepithelial lesions (SILs). Clinical Features Epidemiology Occurs predominantly in postmenopausal women. Also can be seen in any low-estrogen state (postpartum, breast-feeding). You’re…
D efinition —The presence of two different human papillomavirus (HPV)–type specific lesions in the same specimen. Clinical Features Epidemiology Reproductive-age, sexually active women, in the vulva or anal region may be associated with immunosuppression but not specific for this condition.…
D efinition —Immature condyloma represents an infection of the immature metaplastic cervical transformation zone epithelium by human papillomavirus (HPV) type 6 or 11. Also variably called squamous papilloma or papillary immature metaplasia; the most appropriate term is low-grade squamous intraepithelial…
PITFALL D efinition —A variant of condyloma that presents as a grossly enlarged mass and appears to replace or cover the cervix and/or distal vagina. Clinical Features Epidemiology Sexually active, reproductive-age women. Uncommon. You’re Reading a Preview Become a Clinical…
D efinition and T erminology A precancerous lesion arising at the cervical squamocolumnar (SC) junction that displays near full-thickness atypia and variable maturation of the neoplastic epithelium. Should be associated always with high-risk human papillomaviruses (HPVs) and with HPV16 in…