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Muscle weakness and wasting
Muscle weakness and wasting may be caused by a variety of conditions both systemic and those confined to the muscles only.
Causes
Localised
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Peripheral nerve lesions
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Peripheral nerve compression
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Motor neuropathy
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Peripheral nerve transection
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Disuse atrophy
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Anterior horn cell lesions
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Previous poliomyelitis • (common in developing countries)
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Generalised
Nutritional deficiency
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Vitamin D deficiency
Systemic disease
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Malignancy
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Cardiac and/or respiratory cachexia
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Thyrotoxicosis
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Sarcoidosis
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Guillain–Barré syndrome
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Cushing’s disease
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Addison’s disease
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