Category Pathology

Toxemia

D efinition — A hypertensive disorder that arises during pregnancy; there are five types. Clinical Features Epidemiology Hypertensive disorders that fall under the umbrella of “toxemia of pregnancy” are common occurrences. Their presentations are varied and described in the following…

Toxoplasmosis

D efinition — A parasitic infection often contracted by handling cat litter, which can result in significant fetal morbidity if primary maternal infection occurs in the first trimester. Clinical Features Epidemiology Affects approximately 3500 newborns each year in the United…

Placenta Previa

D efinition — Placental implantation within the lower uterine segment, overlying the cervical os. Clinical Features Epidemiology Placenta previa is a common finding in early pregnancy. The majority of cases spontaneously resolve during gestation. Less than 1% of cases persist…

Placenta Creta

D efinition — Abnormal adherence of the placenta to the uterine wall. Clinical Features Epidemiology Placenta creta occurs in 1 in 2500 pregnancies. Historically all subtypes of placenta cretas were rare. More than 80% of cases occur in patients with…

Fetal Leukemia

D efinition — A primary white blood cell malignancy arising in the fetus. Clinical Features Epidemiology Fetal leukemia is exceedingly rare and has an incidence of approximately four to five per million live births. Fetal leukemia is the leading cause…

Inflammatory Abruption

D efinition — Early separation of the placental disk from the underlying maternal surface. Clinical Features Epidemiology Placental abruption is a relatively common event, with an overall incidence of 1%. Numerous predisposing factors are thought to lead to abruption but…

Lysosomal Storage Disorder

D efinition — Metabolic deficits within the fetus that lead to the accumulation of a metabolite, typically visible in the placental villi. Clinical Features Epidemiology Lysosomal storage disorders and their placental presentations are rare events. The vast majority of cases…

Congenital Syphilis

D efinition — Infection resulting from the spirochete Treponema pallidum . Clinical Features Epidemiology The frequency of congenital syphilis in developed countries is much lower; however, a recent rise in the incidence has been noted. It is rarely encountered in…