Introduction Back pain is prevalent in the United States and worldwide. Lumbar arthrodesis techniques are being increasingly used to address congenital, degenerative, and traumatic spinal pathologies. Adjacent segment degeneration continues to be a very common sequela of lumbar arthrodesis occurring…
Introduction Anterior cervical decompressions and fusions (ACDFs) are one of the most common spine surgeries worldwide and the gold standard treatment for symptomatic cervical spondylosis. Adjacent segment disease is a very common sequela and occurs in about 26% of all…
Introduction The intervertebral disc allows axial loading that results from an upright posture of the spine. The disc is composed of two components, the outer fibrous annulus fibrosus and the central nucleus pulposus, and originates from the notochord. The nucleus…
Introduction Low back pain is prevalent in the United States and the world, and spondylolisthesis is one of the most common causes of back pain with an estimated prevalence of 11.5%. Spondylolisthesis refers to the anterior, posterior, or rotational translation…
Introduction Spondylolisthesis was first described by Herbiniaux, who noted the presence of a lumbar vertebrae ventral to the sacrum causing an obstruction to the progression of labor during a routine pelvic exam. The term “spondylolisthesis,” however, was not used until…
© 2018 Elsevier Inc. All rights reserved. Please note that the copyright for the original figures submitted by the contributors is owned by Contributors. Patient advocacy is the endeavor where laypeople advocate for patients, survivors and caregivers inside the healthcare…
Introduction The Chordoma Foundation (“CF”) is a global nonprofit organization whose mission is to improve the lives of those affected by chordoma and lead the search for a cure. CF unites multiple stakeholders—patients, caregivers, doctors, scientists, drug developers, and others—to…
© 2018 Elsevier Inc. All rights reserved. Please note that the copyright for the original figures submitted by the contributors is owned by Contributors. Chordoma Prognostic Factors Patient age at diagnosis, tumor characteristics including pathological features, molecular markers, and cytogenetics,…
© 2018 Elsevier Inc. All rights reserved. Please note that the copyright for the original figures submitted by the contributors is owned by Contributors. Introduction: Barriers to Traditional Therapies Chordoma and chondrosarcoma are closely related malignant tumors; in fact, a…
© 2018 Elsevier Inc. All rights reserved. Please note that the copyright for the original figures submitted by the contributors is owned by Contributors. Chordoma Given the rarity of chordoma, prospective data to guide treatment are limited. Historically, definitive treatment…