Standard-of-care radiation regimens Historical Context of Radiation Therapy and Dose Historically, standard treatment for glioblastoma (GBM) was surgical resection alone. The first randomized trial to show a survival benefit with adjuvant radiation therapy (RT) was the Brain Tumor Study Group…
Acknowledgments The authors would like to acknowledge our colleagues and teachers in neuroradiology at the University of Pennsylvania for their insights on brain tumor imaging, particularly Drs Ronald Wolf, Linda Bagley, Suyash Mohan, and John Woo. Introduction Neuroimaging plays a…
Introduction With an incidence of 3 to 5 per 100,000, glioblastoma fulfills the criteria of a rare cancer. Despite this, glioblastoma is the most common and most aggressive primary brain tumor and accounts for 12% to 15% of all intracranial…
Acknowledgments This work was supported by National Institutes of Health grants R00HL103792 and R01NS094533 , University of Pennsylvania Neuro-oncology Innovation Award, and McCabe Award (to Y. Fan). Glioma is the most common malignant primary tumor in the central nervous system,…
Acknowledgments The authors are grateful to their NYU Langone Medical Center colleagues Matija Snuderl, MD, for contributing illustrated cases of cytogenetics analysis and methylation array; Cyrus Hedvat, MD, PhD, for providing an illustrated case of loss of heterozygosity analysis; and…
The cellular origin of glioblastoma is complex. Despite decades of research, the understanding of the cellular, molecular, and pathogenetic architecture of this lethal disease is still evolving. Other chapters discuss the epidemiology, risk factors, associated clinical outcomes, and molecular targeting…
Incidence of glioblastoma Gliomas are the most common type of malignant brain tumor in adults. Of the gliomas, glioblastoma (astrocytoma grade IV) is the most common, and represents approximately 27% of all primary brain tumors, and 80% of malignant primary…
Glioblastoma remains a formidable pathologic entity. Without the tools necessary to make a neurologic diagnosis, early medical and surgical clinicians were likely not only puzzled but also appalled by the downward trajectory of patients affected by this tumor. The development…
The original excitement of participating in large, complex and long surgical cases to treat craniosynostosis during our training years gave way to disappointment, frustration, and dissatisfaction with the long-term clinical results of these surgeries. Even though the patients immediately looked…
Introduction Review of complications associated with the surgical treatment of craniosynostosis varies widely due to reports that extend over many years and epochs, as well as there being a large number of different procedures being reported during these periods. A…