D efinition —“Ectopic,” colonic-type neoplasia (adenoma/carcinoma) arising in the vaginal or vulvar mucosa. Clinical Features Epidemiology Origin is in colonic-type epithelium, presumably incorporated into the vaginal or vulvar region following formation of the urorectal septum in early development. Another possible…
D efinition —A malignant mucocutaneous neuroendocrine neoplasm. Clinical Features Epidemiology Very rare (~12 per year in the United States). Vulvar tumors account for about 3% of all Merkel cell carcinomas. Risk factors include age (>60 years) and sun exposure. You’re…
D efinition —Infiltration of the squamous epithelium by mucin-producing neoplastic cells. Clinical Features Epidemiology Uncommon; represents only 1% to 2% of vulvar malignancies. The average age at presentation is 65 years; the majority of patients are over 50 years. You’re…
D efinition —An aggressive variant of squamous cell carcinoma with conspicuous glandular differentiation. Clinical Features Epidemiology Uncommon. Mean age at diagnosis is 65 to 70 years. Associated with chronic vulvar inflammatory disease. Human papillomavirus (HPV) link is unclear but likely…
D efinition —An uncommon, nonmetastasizing (usually!) but locally destructive carcinoma of basal keratinocytes with characteristic peripheral nuclear palisading. Clinical Features Epidemiology Rare. Not human papillomavirus (HPV) associated. Elderly women in their 70s and 80s. You’re Reading a Preview Become a…
PITFALL D efinition —A neoplastic proliferation of keratinocytes arising in follicular epithelium. Clinical Features Epidemiology Typically occurs in the middle aged to elderly. Suspected causes include ultraviolet light, immunosuppression, genetic alterations, chemical exposure, viruses, and trauma. You’re Reading a Preview…
PITFALL D efinition —A reactive condition marked by acanthosis and irregular epithelial architecture. Clinical Features Epidemiology Noncontributory. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member.…
PITFALL D efinition —A papillosquamous lesion of significant size, histologically indistinguishable from generic condyloma. Clinical Features Epidemiology A rare entity that most commonly affects young men. Seen more commonly in immunosuppressed patients (human immunodeficiency virus [HIV] positive). Can also be…
D efinition —A papillary exophytic squamous lesion similar in morphology to vulvar intraepithelial neoplasia (VIN) III but with risk of underlying invasion. Clinical Features Epidemiology Identical to that of a classic or usual high-grade VIN. May be associated with an…
D efinition —Invasive epithelial neoplasm composed of keratinocytes involving the vulva. Exhibits a distinct histology and invasive pattern that is nonmetastasizing. Clinical Features Epidemiology Typically affects women in their seventh and eighth decades and is usually found associated with inflammatory…