D efinition —Classic or “usual-type” vulvar intraepithelial neoplasia (VIN) with full-thickness atypia similar to that seen in bowenoid papulosis but with milder atypia. Clinical Features Epidemiology Consists of a fraction of the patients with classic VIN. May be seen in…
PITFALL D efinition —Human papillomavirus (HPV)-associated squamous intraepithelial lesion (SIL) with superimposed changes of lichen simplex chronicus (LSC). Clinical Features Epidemiology Affects a fraction of the patients with classic vulvar intraepithelial neoplasia (VIN). You’re Reading a Preview Become a Clinical…
D efinition —Classic (usual) high-grade squamous intraepithelial lesions of the vulva are defined as full-thickness or near full-thickness atypias associated with high-risk or carcinogenic human papillomavirus (HPV) infections, principally HPV 16. Clinical Features A wide age range, from second to…
D efinition —Flat condyloma is defined as a macular variant of condyloma that falls within the category of low-grade squamous intraepithelial lesion (LSIL) and displays an identical distribution of atypia as its exophytic counterpart. In contrast to exophytic condylomas, these…
PITFALL D efinition —An unusual variant of condyloma that is marked by a striking increase in apoptosis in the upper epithelial layers. Clinical Features Epidemiology Occurs in the same demographic groups as typical condyloma; however, disease is secondary to more…
D efinition —A benign, warty proliferation of keratinocytes that is frequently pigmented and often associated with low-risk human papillomavirus (HPV) (types 6 and 11). Clinical Features Epidemiology Can be seen in all age groups. A large percentage are associated with…
D efinition —Benign polypoid vulvovaginal lesions of young- to middle-aged women with a striking array of histologic appearances, often associated with pregnancy. Clinical Features Epidemiology Young- to middle-aged women. Multiple lesions are associated with pregnancy. Very rare before menarche. You’re…
D efinition —A solitary acanthotic and dyskeratotic epidermal proliferation. Clinical Features Epidemiology Rare disease, most often seen in the head and neck regions. Very rarely involves the vulva. Not an inherited condition (as opposed to Darier's disease). You’re Reading a…
D efinition —Verruciform xanthoma is a solitary benign verrucous lesion of the vulva that contains foamy histiocytes in the lamina propria. Clinical Features Middle-aged women. Solitary wartlike growth on the genital area. No relationship to human papillomavirus (HPV). You’re Reading…
D efinition —Benign squamous tumors caused by infection of human papillomavirus (HPV). In this chapter condyloma includes two verruciform variants: classic condyloma and fibroepithelial papilloma. A third, seborrheic, keratosis-like condyloma will be discussed separately. Clinical Features Epidemiology Very common sexually…