D efinition —Invasive epithelial neoplasm composed of keratinocytes involving the vulva. Human papillomavirus (HPV) negative. Clinical Features Epidemiology Typically affects women in their seventh and eighth decades and is usually found associated with inflammatory dermatosis (differentiated vulvar intraepithelial neoplasia [VIN]).…
D efinition —Invasive epithelial neoplasm composed of keratinocytes involving the vulva. Comprise tumors associated with classic vulvar intraepithelial neoplasia (VIN). Clinical Features Epidemiology Typically affects women in their sixth decade but can be seen in women under 40 who are…
D efinition —Invasion less than 2 cm in diameter and to a depth of less than 1 mm below the highest epithelial–stromal interface. Epidemiology A wide age range, from second to eighth decade, predominating in the fifth and sixth decades. Patients typically…
D efinition —Vulvar acanthosis with altered differentiation (VAAD) is defined as vulvar acanthosis with variable verruciform architecture that lacks the nuclear atypia characteristic of vulvar intraepithelial neoplasia (VIN) but exhibits abnormalities in keratinocyte differentiation. It is classed as a risk…
D efinition —A clinical and pathologic response to continued physical trauma comprised of markedly thickened skin with verruciform changes along with erythema and plaquelike scaling. Clinical Features Epidemiology Seen in all demographic groups; however, has been associated with vulvar cancer…
D efinition —Vulvar intraepithelial neoplasia (VIN) that likely is secondary to a series of host gene alterations that are discrete from those involved in classic VIN. Clinical Features Epidemiology Occurs in postmenopausal women but can be seen earlier. Associated with…
D efinition —A reactive epithelial process seen in skin or vulva characterized by a cytoskeletal defect with accumulation of nuclei in individual cells (multinucleation). Clinical Features Epidemiology No particular demographic other than an association with nonspecific, chronic, irritative, or inflammatory…
PITFALL D efinition —A variant of epithelial atypia associated with gamma papillomaviruses, classically associated with epidermodysplasia verruciformis (EDV) but now appreciated in immunosuppressed (including human immunodeficiency virus [HIV]–infected) patients and involves the vulva. Clinical Features A wide age range. Multiple…
PITFALL D efinition —A rare variant of vulvar intraepithelial neoplasia (VIN) with lesional columnar (i.e., mucinous) cells. Clinical Features Epidemiology Rare, affects a small fraction of the patients with classic VIN. You’re Reading a Preview Become a Clinical Tree membership…
PITFALL D efinition —An unusual variant of vulvar intraepithelial neoplasia (VIN) in which the more poorly differentiated cells invade the overlying mature squamous epithelium. Clinical Features Epidemiology Rare, affects a small fraction of the patients with classic VIN. You’re Reading…