Definition High-grade carcinoma with neuroendocrine differentiation, morphologically identical to its pulmonary counterpart Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
Definition This category contains very poorly differentiated tumors with mixed morphologies (such as small cell undifferentiated carcinoma), giant cell carcinoma, and large cell undifferentiated carcinoma. Clinical features Epidemiology Rare tumors with limited available information Occurs most commonly in older males You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
Definition The carcinomas of the urothelial tract resembling giant cell tumors of bone Clinical features Epidemiology Rare variant of invasive urothelial carcinoma Male predominance Elderly age (majority in 7 th decade or older) You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
Definition Unusual variant of urothelial carcinoma characterized by presence of cells with prominent rhabdoid features Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
Definition Unusual form of divergent differentiation in urothelial carcinoma characterized by the presence of human chorionic gonadotrophin (hCG) positive syncytiotrophoblastic giant cells or by a choriocarcinoma component Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
Definition Urothelial carcinoma entirely or partially composed of pleomorphic giant cells Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
Definition A rare variant of urothelial carcinoma, characterized by the presence of lipoblast-like epithelial tumor cells with lipid-containing cytoplasmic vacuoles Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
Definition Urothelial carcinoma showing clear cell pattern with glycogen-rich cytoplasm Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
Definition Undifferentiated carcinoma of the urinary bladder with a prominent lymphocytic stroma and morphologic resemblance to the undifferentiated nasopharyngeal carcinoma variant Clinical features Epidemiology The male-to-female ratio is 2:1. Most patients are in late adulthood, with a mean age at diagnosis of 70 years. The usual stage at presentation is T2–T3. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited…
Definition A histologic variant of urothelial carcinoma that is composed of malignant urothelial nests, usually with low-to-intermediate nuclear grade, with microcyst, macrocyst and tubular formation. Usually occurs in the bladder with rare cases in the renal pelvis Clinical features Epidemiology Affects adult men and women You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are…
Definition Morphologically distinct variant of invasive urothelial carcinoma Clinical features Epidemiology Incidence <1% to 2.2% of all invasive urothelial carcinomas Most common in the sixth decade (range, 45 to 91 years) Males more frequently affected (male-to-female ratio, 5:1) You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
Definition A rare variant of urothelial carcinoma composed of cytologically bland cells that infiltrate in individual or crowded nests Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
Definition A rare variant of urothelial carcinoma composed of cells that resemble plasma cells and/or monocytes Also known as signet cell or diffuse variant Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
Definition Urothelial carcinoma associated with both villous and glandular components Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
Definition Urothelial carcinoma shows focal or extensive areas of keratin production or intercellular bridge formation. Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
Definition Noninvasive low- or high-grade urothelial carcinoma showing an inverted–endophytic pattern of growth; may have a coexisting exophytic papillary component Clinical features Epidemiology Relatively uncommon You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
Definition Carcinoma derived from the urothelial lining of the urinary tract that invades into the underlying tissues Clinical features Epidemiology Urothelial carcinoma occurs most often in the urinary bladder with lower incidence in the kidneys, ureters, and urethra. Urothelial carcinoma is the most common type of bladder cancer in the United States. Males are affected three- to fourfold more frequently than are females. Smoking and occupational…
Definition Papillary urothelial neoplasm shows significant architectural and cytologic atypia that are apparent at low magnification Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
Definition Papillary neoplasm lined by urothelium with easily recognizable variation in cytologic features and characterized by an overall orderly appearance of the urothelium lining papillary fronds Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
Definition Papillary urothelial tumor with abnormally thick urothelium, but lacking cytologic atypia Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here