Hypercalcaemia is a serum calcium >2.62 mmol/L (normal range 2.1–2.6 mmol/L). It may be an asymptomatic laboratory finding. Symptoms usually become apparent with levels >3.50 mmol/L.

Causes

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    Malignancy

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      Solid tumour with lytic bony metastases, e.g. Ca breast, bronchus

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      Solid tumours with humoral mediation, e.g. inappropriate PTH secretion with carcinoma of the bronchus, carcinoma of the kidney

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      Multiple myeloma

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    Hyperparathyroidism (primary, secondary, tertiary)

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    Hyperthyroidism

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    Drugs, e.g. thiazide diuretics, lithium

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    Addison’s disease

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    Paget’s disease of bone

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    Excess intake of vitamin A, vitamin D or calcium

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    Sarcoidosis

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    Familial hypocalciuric hypercalcaemia

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