Introduction Perhaps the most frequent use of diagnostic immunohistochemistry (IHC) in the surgical pathology laboratory pertains to breast biopsies by virtue of the volume and sheer difficulty of cases. In addition to utilizing IHC for diagnostic problems with breast biopsies,…
This chapter focuses on the use of immunohistochemistry (IHC) in the setting of diagnostic gynecologic pathology. The first section describes the properties and applications of most useful antibodies for the evaluation of lesions in the gynecologic tract. The second section…
Overview The unprecedented advances in cancer genetics and genomics are rapidly affecting the clinical management of solid tumors. Molecular diagnostics are now an integral part of routine clinical management for patients with lung, colon, breast, and gynecologic malignancies among others.…
Overview Used in the proper setting, ancillary techniques can be a great adjunct to light microscopy to obtain an accurate diagnosis in urologic pathology. In the last decade, a plethora of molecular biomarkers have been evaluated for their potential role…
Acknowledgment The authors thank Dr. Hulya Sahin Ozkan for her contributions in the preparation of this chapter. In the ensuing chapter, the cellular lineage markers and the application of immunohistochemistry (IHC) in the diagnosis and management of specific tumor types…
Acknowledgment We would like to acknowledge and thank Jeffrey Goldsmith, MD, for his significant contributions to prior editions of this chapter. This chapter divides the discussion of immunohistochemistry (IHC) of the luminal gastrointestinal (GI) tract into three sections: (1) epithelial…
Overview The skin is a complex microenvironment. The normal structures of the epidermis, dermis, and cutaneous adnexa are morphologically and functionally complicated, and the histologic entities that occur in this tissue compartment are also numerous. Furthermore, cutaneous lesions may also…
The use of immunohistochemistry (IHC) as an aid in the diagnosis of surgical pathology has changed the practice of pathology, as its use is more widespread with more available antibodies to enhance diagnostic specificity. In addition, with the current availability…
Introduction In general, mediastinal pathology is rich in terms of the diversity of neoplasms that may occur primarily in the mediastinal cavity. However, in the context of occurrence, mediastinal tumors are rare. In addition, over the last decades some of…
Acknowledgments We want to thank our former co-authors, Dr. Ronald A. DeLellis and Dr. Sandra J. Shin for their significant contributions to the previous versions of this chapter. Overview Immunohistochemical (IHC) methods have had a profound impact on the understanding…