Introduction As a dermatologist walks into the examination room of the patient in Fig. 123.1 , several diagnostic possibilities likely come to mind. The patient's history, additional physical findings, and other clues help narrow the differential diagnosis. In this case,…
Key features ▪ Cutaneous metastases are uncommon and rarely may be the presenting sign of an internal malignancy ▪ In general, cutaneous metastases are associated with a poor prognosis ▪ In women, breast carcinoma and melanoma are the malignancies that…
Benign Lymphocytic Infiltrates Lymphocytic Infiltrate of Jessner Synonyms ▪ Lymphocytic infiltrate of Jessner–Kanof ▪ Benign lymphocytic infiltrate of the skin ▪ Jessner lymphocytic infiltrate ofthe skin ▪ Jessner lymphocytic infiltration of the skin ▪ Jessner–Kanof lymphocytic infiltration of the skin…
Introduction The term cutaneous T-cell lymphoma (CTCL) describes a heterogeneous group of neoplasms of skin-homing T cells that show considerable variation in clinical presentation, histologic appearance, immunophenotype, and prognosis. CTCLs represent approximately 75–80% of all primary cutaneous lymphomas, whereas primary…
Synonyms ▪ Cutaneous B-cell lymphomas ▪ S kin- a ssociated l ymphoid t issue (SALT)-related B-cell lymphomas Key features ▪ Cutaneous B-cell lymphomas represent a group of lymphomas whose primary site is the skin; they are derived from B lymphocytes…
Key features ▪ Mastocytosis can develop from birth to adulthood and may involve only the skin (most children and some adults) or multiple organs such as the bone marrow, liver, spleen, and/or lymph nodes (primarily adults) ▪ Childhood disease is…
Introduction Smooth muscle, adipose and cartilage neoplasms arising in the skin and subcutis comprise a wide spectrum of benign and malignant neoplasms that show myocyte, adipocyte, and chondrocyte differentiation, respectively. Tumors of fat, especially lipomas, occur most commonly. These neoplasms…
Key features ▪ Fibrous and fibrohistiocytic proliferations of the skin and tendons are common lesions that include both neoplastic and “reactive” processes ▪ Common benign fibrous and fibrohistiocytic proliferations, some of their atypical variants that could be misdiagnosed as malignant…
In the past, neural tumors were often misdiagnosed histopathologically because of confusing classifications. As a result, their clinical relevance was poorly understood. Clinically, cutaneous neural tumors often look alike and most of them are benign. However, their correct diagnosis can…
Introduction In this chapter we use the term neoplasm synonymously with tumor in a general, albeit imperfect , sense, consistent with its common usage: an abnormal proliferation (“new growth”) of cells that appears to be relatively autonomous (i.e. not reactive)…