Synonyms ▪ Hemangioma of infancy ▪ Hemangioma Key features ▪ The most common benign soft tissue tumor of infancy ▪ Demonstrate a typical growth pattern characterized by early proliferation followed by gradual, spontaneous involution ▪ Distinct histopathologic and immunohistochemical features…
Key features ▪ Cutaneous blood vessels and lymphatic vessels play important roles in skin inflammation and tumor progression ▪ Vascular endothelial growth factor-A (VEGF-A) and placental growth factor (PlGF) are major skin angiogenesis factors ▪ Expression of VEGF and PlGF…
Synonyms ▪ Lipodystrophy: lipoatrophy, lipohypertrophy Key features ▪ Lipodystrophies are inherited or acquired disorders characterized by a paucity or complete absence of fat that may be generalized, partial or localized; lipohypertrophy may accompany the lipoatrophy ▪ Though the terms lipodystrophy…
Introduction Panniculitis is a diagnostically challenging arena for dermatologists and pathologists. Terminology is difficult, partly because various names have been applied to the same disorder (e.g. nodular vasculitis and erythema induratum), and partly because new discoveries have resulted in the…
Atrophies of the skin that are due to a diminution or loss of collagen and/or elastic fibers are discussed in this chapter. The areas of involvement can be quite large, as in mid-dermal elastolysis, or punctate, as in follicular atrophoderma.…
This chapter will discuss disorders in which there are increased amounts of collagen within the skin, followed by those with increased elastin. Hypertrophic Scars and Keloids Key features ▪ Conventional scars are preceded by injury, immediate in onset, flat, and…
Key features ■ Heritable connective tissue disorders with skin involvement comprise a phenotypically diverse group of conditions ■ Recognition of characteristic skin findings is often critical to establishing the diagnosis and identifying associated internal involvement, which may include life-threatening cardiovascular…
Synonyms ▪ Hyperkeratosis follicularis et parafollicularis in cutem penetrans: Kyrle disease ▪ Acquired perforating dermatosis: acquired reactive perforating collagenosis, acquired reactive perforating dermatosis, perforating disorder of uremia Key features ▪ Group of disorders with transepidermal elimination of collagen, elastic tissue,…
Key features ▪ Extracellular matrices (ECMs) represent specifically organized networks of collagens, elastin, glycoproteins, and proteoglycans that have distinct structural roles and specific functional properties in all tissues ▪ ECMs are biologically active, interact with cells, and regulate their functions…
Key features ▪ Foreign body reactions represent inflammatory responses to inorganic and high-molecular-weight organic materials that have been introduced into the skin and are variably resistant to degradation ▪ Routes of introduction can vary from accidental or self-inflicted to surgical…