See also Polyoxylated castor oil General information Propanidid was used as an intravenous anesthetic for rapid induction and for maintenance of general anesthesia of short duration. However, it was withdrawn because of safety considerations regarding the solvent used, polyoxylated castor…
General information Propafenone is both a class I antidysrhythmic drug and a beta-adrenoceptor antagonist. Its pharmacological effects, clinical pharmacology, therapeutic uses, adverse reactions, and interactions have been reviewed [ ]. The main adverse reactions to propafenone are cardiovascular (27%), central…
See also Antihistamines General information Promethazine is a first-generation antihistamine, and can cause sedation and impaired psychomotor activity [ , ]. Organs and systems Nervous system Neuroleptic malignant syndrome has been associated with promethazine [ ]. A 42-year-old man took…
See also Amphetamines General information Prolintane, an amfetamine-related substance, is a central nervous system stimulant with similar structure and properties to dexamfetamine. Prolintane hydrochloride is available mainly in many formulations with multivitamin supplements in many European countries, Australia, and South…
General information Proguanil is one of the antimalarial drugs most widely used for prophylactic purposes, usually in combination with chloroquine or atovaquone in malaria prophylaxis, and with atovaquone in malaria treatment [ ]. A biguanide, it is rapidly absorbed in…
See also Non-steroidal anti-inflammatory drugs (NSAIDs) General information Proglumetacin, an indoleacetic acid derivative, is a non-steroidal anti-inflammatory drug and can cause gastrointestinal adverse reactions: in different trials 18–41% of patients had adverse reactions, although not to the extent that they…
See also Hormonal contraceptives – emergency contraception ; Hormonal contraceptives—progestogen implants ; Hormonal contraceptives—progestogen injections General information Most aspects of progestogens are dealt with in the monograph on hormonal contraception. For a complete account of the adverse effects of progestogens,…
General information Progabide acts, together with its metabolites, as an agonist at both GABA A and GABA B receptors. It has been used in the treatment of spasticity [ , ], epilepsy and movement disorders [ , ], and benign…
See also Anticholinergic drugs General information Procyclidine is an anticholinergic drug [ ]. The usual oral dose, 20–30 mg/day, is likely to produce only mild anticholinergic adverse reactions, but involuntary movements, with chewing and sucking, have been described in some…
See also Neuroleptic drugs General information Prochlorperazine is a phenothiazine derivative. Organs and systems Cardiovascular There was an association between the use of antipsychotic drugs and the risk of venous thromboembolism in a large nested case-control study using the UK…