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Key points Definition: Optic nerve glioma (ONG) is a type of juvenile pilocytic astrocytoma (grade 1 astrocytoma) that occurs more commonly in children and young adults. Synonym: Optic pathway glioma (OPG). Classic clue: Sausage-shaped diffuse fusiform enlargement and “kinking” of the intraorbital optic nerve (ON). More favorable prognosis compared to other astrocytoma types. Most common primary neoplasm of the ON. Bilateral ONG is pathognomonic of neurofibromatosis…

Key points Definition: Orbital cavernous hemangioma is a benign, slow-growing, vascular lesion manifesting as painless, progressive proptosis. Synonyms: Ocular cavernous hemangioma, orbital cavernous malformation, orbital cavmal. Classic clue: Well-circumscribed, enhancing intraconal mass in adult patients. Usual imaging appearance Computed tomography (CT) features: Intraconal mass. Homogeneous, well-circumscribed. Enhancement ↑↑↑↑. Magnetic resonance imaging (MRI) features: T1 isointense. T2 hyperintense. T1 + Gd enhancement. “Blooming” artifact. Most common orbital…

Key points Definition: Retinal detachment (RD) is a condition in which the inner retinal layer peels away from the middle choroidal layer of the globe permitting fluid to accumulate in what was previously only a “potential space.” It is a true medical emergency, progressing to vision loss and permanent blindness if not repaired within 24 to 72 hours. Classic clue: Middle-aged or older patient presents with…

Key points Definition: An ocular prosthesis (OP) is a device that replaces the native eye after enucleation, evisceration, or exenteration. Also known as: glass eye, artificial eye. Classic clue: The patient usually visits the radiology department for neuro computed tomography (CT) or magnetic resonance imaging for a problem totally unrelated to the OP and the device is first found by an unsuspecting resident or fellow with…

Key points Definition: Phthisis bulbi (PB) is a generic descriptive term for the ocular globe’s “end-stage” appearance after wasting away, becoming anatomically disfigured, and shrunken as a result of a range of possible prior insults. Also known as: end-stage eye, blind hypotensive eye, ocular phthisis, atrophia bulbi, atrophy eyeball, shrunken eyeball, phthisis eyeball, eyeball atrophy, and others. Classic clue: Patient commonly presents with unilateral blindness related…

Key points Definition: Ruptured globe (RG) occurs when the integrity of the eye is breeched by blunt or penetrating trauma causing full-thickness corneal or scleral breech. This is an ophthalmologic emergency. Synonym: Shattered globe. Classic clue: A man in his 30s with eye pain after having been struck by a projectile while carrying out a home-improvement project is sent by the emergency department with a request…

Key points Definition: Ocular lens displacement (OLD) refers to the malposition of the lens relative to its normal location as a result of disruption of the zonular fibers, which normally connect the lens to the ciliary body. Synonyms: Lens luxation, lens subluxation, dislocation of lens, ectopia lentis . Classic clue: The patient presents posttrauma with visual disturbance, monocular diplopia, reduced visual acuity, reduced near vision, and…

Key points Definition: Anterior chamber perforation causes loss of aqueous humor resulting in flattening or obliteration of the space between the lens and cornea. Classic clue: The patient presents with potentially penetrating eye trauma, and is found to have a small anterior chamber compared with the contralateral eye. Imaging Computed tomography features Imaging may be requested to locate intraocular or intraorbital foreign bodies. The patient may…

Key points Definition: Blowout orbital floor fractures can be repaired using titanium mesh, which gives a characteristic recognizable imaging appearance on computed tomography (CT) and magnetic resonance imaging (MRI). Classic clue: The patient presents for CT or MRI for his or her current complaint, frequently trauma to the head or face. Neither the patient nor the referring physician mentions the fact that the patient has undergone…

Key points Definition: Orbital exenteration (OE) is a radical surgical procedure involving removal of the entire orbital contents and periorbital structures. It is usually performed to treat primary orbital or periorbital malignancies that invade the orbit. Classic clue: A middle-aged man with basal cell carcinoma (BCC) near the orbit. It had been there a “long time and he thought it would go away,” but he developed…

Key points Definition: Blowout orbital floor fractures (BOFFs) result from direct trauma to the orbit transmitting force to the globe. This causes the orbital contents to “blow out” through the path of least resistance, usually the paper-thin lamina papyracea or the orbital floor. Synonym: Internal orbital fracture. Classic clue: Bowing or displacement of the inferior orbital wall in a patient with known or presumed facial trauma…

Key points Definition: Medial blowout fractures (MBOFs) result from direct trauma to the orbit transmitting most of the force to the globe. This causes the orbital contents to “blow out” through the path of least resistance, usually the paper-thin lamina papyracea or orbital floor. Classic clue: Bowing or displacement of the medial orbital wall in a patient with known or presumed facial trauma and soft tissue…

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This chapter reinforces concepts presented in this textbook. Students of medicine gather pearls of wisdom from their mentors that may not fit well into a didactic treatment of a subject but are valuable in day-to-day practice. We all learn to avoid pitfalls that arise that have escaped our formal education. Interpretative questions require assembling multiple bits of information for a correct answer, and these questions are…

A number of noninvasive cardiac diagnostic imaging studies are available to the cardiologist, which include echocardiography, computed tomography (CT), CT angiography, and magnetic resonance imaging. The continuing value of cardiac nuclear scintigraphic studies is that they are noninvasive, contrast media is not required, and they accurately portray a wide range of physiological and metabolic parameters that predict prognosis and risk. Single-photon emission computed tomography (SPECT) and…

Infection imaging has long been an important indication for scintigraphy. Gallium-67 citrate (Ga-67) was the first infection-seeking radiopharmaceutical used clinically. It is still in use today, however, in a much more limited role than in the past. For decades now, In-111 oxine leukocytes have been the primary radiopharmaceutical used to detect infection. Tc-99m hexamethylpropyleneamine oxime (HMPAO)–labeled leukocytes have also found a role. In recent years, Fluorine-18…

Molecular imaging examinations using positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are frequently used in the brain because they can complement the anatomical information from magnetic resonance (MR) imaging and computed tomography (CT). By examining cellular function, disease is often detected at an earlier stage, or the extent of disease may be more accurately demonstrated with nuclear medicine techniques. Hybrid cameras combining PET…

This chapter reviews tumor scintigraphy using radiopharmaceuticals other than F-18 fluorodeoxyglucose (FDG), as well as therapeutic radiopharmaceuticals for specific malignancies ( Box 13.1 ). Theranostics is a topic of increasing importance as it relates to nuclear oncology. The term refers to a pharmaceutical that is labeled with one radionuclide for diagnostic imaging and another radionuclide for therapy, for example, Ga-68 dotatate and Lu-177 dotatate for neuroendocrine…

Background For decades, positron emission tomography (PET) imaging was largely limited to use in research. The development of dedicated PET cameras, the widespread expansion of cyclotron production facilities, and the approval of new radiopharmaceuticals have all contributed to the dramatic growth of clinical PET in recent years. PET agents often incorporate radioactive isotopes of atoms normally present in organic substances (e.g., oxygen-15, nitrogen-13, carbon-11, and the…