D efinition — A developmental rest of adrenal tissue in the adnexal soft tissue. Clinical FeatureS Epidemiology Can be seen at all ages and in up to one fourth of fallopian tubes examined. Presumably adrenal rests are misplaced deposits of adrenal tissue. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log…
D efinition — A malignant lymphoid process involving the reproductive tract. Clinical Features Epidemiology Reproductive tract lymphoma is exceedingly rare but about two thirds will be primary tumors. In about one third of cases the tumor will be a manifestation of a systemic lymphoma. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a…
D efinition — A tumor composed of a morphologically and immunohistochemically distinct cell type with features of smooth muscle and melanocytic differentiation. Clinical Features Epidemiology Very rare; a somewhat controversial diagnosis at this site (uterus). Cases have been reported in a wide age range (40s to 80s). You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If…
D efinition — A distinctive histopathologic variant of uterine leiomyosarcoma. Clinical Features Epidemiology Rare. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
D efinition — An aggressive histologic variant of uterine leiomyosarcoma. Clinical Features Epidemiology Rare, even among uterine leiomyosarcomas. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
D efinition — A malignant tumor of smooth muscle originating in the myometrium. Clinical Features Epidemiology Rare (estimated incidence of 0.64 per 100,000 women). Account for 1% of all uterine malignancies and more than 25% of uterine mesenchymal malignancies. Mostly occurs in postmenopausal women. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a…
PITFALL D efinition — A unique variant of uterine smooth muscle tumor associated with a genetically transmitted increased risk of renal cell carcinoma (RCC) (loss of heterozygosity [LOH] at 1q43). Clinical Features Epidemiology The underlying defect is a germ-line heterozygous loss of function mutation in the fumarate hydratase gene with LOH at 1q43. Cases can be both germ-line and sporadic. Patients typically (77%) present with leiomyomas,…
D efinition — Changes in the myometrium following an embolization procedure for a presumed leiomyoma using synthetic material. Clinical Features Epidemiology Uterine embolization procedures are performed about 25,000 times per year in the United States. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
D efinition — An uncommon disorder marked by the presence of multiple smooth muscle tumors that are scattered throughout the peritoneum and omentum. Clinical Features Epidemiology Disseminated peritoneal leiomyomatosis (DPL) is a rare disorder. It is most commonly seen in reproductive-age women; however, cases have been identified after menopause. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become…
D efinition — A specific syndrome caused by the iatrogenic dissemination of a morcellated smooth muscle tumor, which is distinct from spontaneous disseminated peritoneal leiomyomatosis. Clinical Features Epidemiology Power morcellation has been a commonly used technique for removing intraabdominal smooth muscle tumors and may disseminate both normal and tumor tissues in the peritoneal cavity. Unexpected leiomyosarcoma occurs in approximately 1 to 2 per 1000 routine hysterectomies…
D efinition — A variant of leiomyoma in which the tumor is located entirely within vein(s) of the uterus, pelvis, or even the vena cava. Clinical Features Epidemiology Rare. Same patient population as typical uterine leiomyoma. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
D efinition — An unusual smooth muscle tumor of the uterus with a predilection for vascular involvement. Clinical Features Epidemiology Rare. Same patient population as for usual leiomyoma. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
D efinition — Uterine smooth muscle tumor composed of multiple repetitive fascicles of smooth muscle diffusely involving the myometrium without a definable border. Clinical Features Epidemiology Same as for leiomyoma, but extremely rare. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
D efinition — A benign smooth muscle tumor with prominent nuclear atypia. Clinical Features Epidemiology Uncommon. Identified in the same patient population as typical leiomyomata. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
D efinition — A morphologic variant of uterine leiomyoma. Clinical Features Epidemiology Mitotic activity within normal and leiomyomatous smooth muscle cells is a well-established phenomenon. Exogenous progesterones increase the observed mitotic rate in leiomyomata. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
D efinition — Uterine smooth muscle tumor with prominent degenerative changes. Clinical Features Epidemiology Same as for leiomyoma. Degenerative change within leiomyomata is extremely common. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
D efinition A smooth muscle tumor with conspicuous increased cellularity. Clinical Features Epidemiology The same as for usual leiomyoma. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
D efinition — A benign tumor of the uterus composed of both smooth muscle and adipose cells. Clinical Features Epidemiology Rare. Postmenopausal women. t(12;14) a common chromosomal rearrangement similar to other leiomyomas. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
D efinition — A benign tumor composed of smooth muscle and mesothelium that is most common in the outer myometrium and fallopian tube. Clinical Features Epidemiology Uncommon but not rare. Reproductive-age to perimenopausal women. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
D efinition — An endometrial polyp with features suggestive, but not diagnostic, of an müllerian adenosarcoma. Clinical Features Epidemiology Wide age range. Typically fourth to sixth decades. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here