Psychiatry

Limbic System The limbic system is the only brain area receiving major hypothalamic input and providing interconnection with widespread cortical areas. Major limbic structures include the amygdala, piriform cortex (parahippocampal gyrus, uncus + amygdala) , hippocampus, substantia innominata, and septal area. The limbic system's diverse roles include memory, drive, affect, autonomic tone, endocrine control, and immunoregulation. The amygdala is connected extensively to the hypothalamus and other…

Epilepsy

Electroencephalography The electroencephalogram (EEG) is a record of the electrical activity of the nerve cells in the brain. The EEG is based on the measurement of electrical fields generated by volume conduction of ionic currents from nerve cells through the extracellular space. Recorded EEG potentials arise from extracellular current flow from summated excitatory postsynaptic potentials (EPSPs) and inhibitory postsynaptic potentials (IPSPs). The EEG does not record…

Cerebral Cortex and Neurocognitive Disorders

Surfaces of Cerebrum The cerebrum is divided into right and left hemispheres by a longitudinal fissure. Each hemisphere has three surfaces—superolateral, medial, and inferior—all of which have irregular fissures, or sulci, demarcating convolutions, or gyri. Although there are variations in arrangement between the two hemispheres in the same brain and in those from different persons, a basic similarity in the pattern allows the parts of the…

Normal and Abnormal Development

Initial Specification of the Nervous System: The Embryo at 18 Days After fertilization and implantation, the embryo consists of a single cell layer called the inner cell mass. The inner cell mass sits at the bottom of a fluid-filled cavity defined by the key extraembryonic membrane, the amnion. Beneath the embryo is another cavity, the yolk sac, lined with a cell layer called the embryonic hypoblast,…

Hand and Finger

Bones of the Hand Metacarpal Bones Five metacarpals form the skeleton of the hand. They are miniature “long” bones, comprising a shaft, a head, and a base. They are palpable on the dorsum of the hand and terminate distally in the knuckles, which are their heads (see Plates 4-1 and 4-2 ). The shaft is curved longitudinally so as to be convex dorsally and concave on…

Forearm and Wrist

Bones and Joints of Forearm and Wrist Distal Parts of Radius and Ulna The distal end of the radius is broadened because its carpal articular surface is the bony contact of the forearm with the wrist and hand. This surface is concave transversely and anteroposteriorly; it is divided by a surface constriction and a slight ridging into a larger triangular portion laterally and a smaller quadrangular…

Upper Arm and Elbow

Bony Anatomy and Landmarks Anteriorly, the contour of the biceps muscle is seen starting in the upper arm and extending distally into the cubital fossa, which is the inverted triangular depression on the anterior aspect of the elbow. The flexion crease along the anterior elbow is in line with the medial and lateral epicondyles and is 1 to 2 cm proximal to the joint line when…

Shoulder

Bones and Joints of Shoulder The function of the upper extremity is highly dependent on correlated motion in the four articulations of the shoulder. These include the glenohumeral joint, the acromioclavicular joint, the sternoclavicular joint, and the scapulothoracic articulation. The glenohumeral joint has minimal bony constraints, thus allowing for an impressive degree of motion. Scapula Ossification centers of the scapula begin to form during the eighth…

Ankle and Foot

Anatomy of the Ankle and Foot Tendon Sheaths at Ankle The extrinsic tendons of the foot originate as muscles in the leg, and as the tendons cross the ankle they must change their orientation. The retinaculum and the corresponding bony anatomy account for the pulley system that allows this to occur and to generate a mechanical advantage for transmission of force. The retinaculum also prevents bowstringing…

Lower Leg

Compartments of Leg Fasciae and Compartments The fascia lata of the thigh continues into the leg, where it is designated as the crural fascia (see Plate 4-2 ). At the knee, the fascia has many attachments—the patella, patellar ligament, tibial tuberosity, condyles of the tibia, and head of the fibula—that reinforce the medial and lateral patellar retinacula. The fascia is strengthened by expansions of the tendons…

Knee

Anatomy of the Knee Knee Joint The knee is primarily a hinge joint that permits flexion and extension. In flexion, there is sufficient looseness to allow a small amount of voluntary rotation; in full extension, some terminal medial rotation of the femur (conjunct rotation) achieves the close-packed position. The condyles of the femur provide larger surfaces than those of the tibial condyles, and there is a…

Pelvis, Hip, and Thigh

Superficial Veins and Cutaneous Nerves Superficial Veins Certain prominent veins, unaccompanied by arteries, are found in the subcutaneous tissue of the lower limb (see Plate 2-1 ). The principal ones are the greater and lesser saphenous veins, which arise in the venous radicles in the feet and toes. Dorsal digital veins lie along the dorsal margins of each digit, uniting at the webs of the toes…

Spine

Vertebral Column The vertebral column is built from individual units of alternating bony vertebrae and fibrocartilaginous discs. These units are intimately connected by strong ligaments and supported by paraspinal muscles with tendinous attachments to the spine. The individual bony elements and ligaments are described in Plates 1-9 to 1-18 . There are 33 vertebrae (7 cervical, 12 thoracic, 5 lumbar, 5 sacral, and 4 coccygeal), although…

Complications of Fracture

Neurovascular Injury Displacement of fracture fragments or bone ends at a dislocated joint carry the risk of producing compression or laceration of adjacent vessels and nerves (see Plate 9-1 ). Critical neurovascular structures (e.g., the brachial plexus) lie deep in the limb, close to the skeleton, which protects them from injuries. A fracture or dislocation makes nerves or vessels vulnerable to injury from sharp bone fragments…

Soft Tissue Infections

Septic Joint Septic Bursitis The human body contains more than 150 bursae, which are sacs or potential spaces lined with a synovial membrane and containing synovial fluid. Bursae, located in the subcutaneous tissue over bony prominences, permit virtually friction-free movement of the skin over these prominences, minimizing irritation. With excessive irritation or use of a joint, a bursa can become inflamed and swollen as more synovial…

Injury to Musculoskeletal System

Injury to Soft Tissue Three basic mechanisms cause soft tissue injuries: blunt trauma, crushing injury, and penetrating trauma. Blunt and crushing injuries are called closed injuries because they do not penetrate the overlying skin. Penetrating (open) injuries violate the protective skin layer, contaminating the wound and thus producing open injuries. Closed Soft Tissue Injuries Closed injuries are characterized by variable degrees of damage to skin and…

Tumors of Musculoskeletal System

Initial Evaluation and Staging of Musculoskeletal Tumors An understanding of the tumors of the musculoskeletal system requires a thorough knowledge of clinical presentation, natural history, staging characteristics, histopathology, and response to treatment of these tumors. Common bone tumors include myeloma, lymphoma, and metastases from primary breast, lung, kidney, thyroid, and prostate cancers; and these are, in fact, the most common malignant bone lesions in patients older…

Rheumatic Diseases

Rheumatic Diseases The term rheumatic disease refers to any illness characterized by pain and stiffness in or around the joints. These diseases are divided into two main groups: disorders that involve the joints primarily (the different forms of arthritis) and disorders that, although not directly affecting the joints, involve connective tissue structures around the joints (the periarticular disorders, or nonarticular rheumatism). The many types of arthritis…

Congenital and Developmental Disorders

Dwarfism—Overview and Achondroplasia Classification Although hereditary disorders of the skeleton are relatively rare, they attract a great deal of interest. Many of these disorders are associated with short stature, or dwarfism. Dwarfism can be either proportionate or disproportionate. Symmetric shortness of the trunk and limbs is common with proportionate dwarfism. Disproportionate dwarfism, in which either the trunk or limbs are more affected than the other, is…

Metabolic Diseases

Parathyroid Hormone The parathyroid gland regulates the calcium in the extracellular fluid by sensing small changes in calcium levels and rapidly modifying the secretion of parathyroid hormone (PTH). With a fall in the calcium level, PTH secretion is increased and, in turn, leads to increased calcium concentration and suppressed PTH secretion, thus completing a feedback loop. PTH raises the calcium level by promoting the entry of…