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Clotting disorders


Disorders of clotting can present with an increased tendency to clotting (thrombophilia) or a decreased ability to form clots and therefore an increased risk of bleeding.

Causes

Increased clotting

Congenital

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    Factor V Leiden deficiency

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    Protein C deficiency

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    Protein S deficiency

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    Antithrombin III deficiency

Acquired

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    Malignancy

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    Pregnancy

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    Infection

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    Prolonged immobility

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    Autoimmune: anti-phospholipid syndrome (can be related to SLE)

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    Drugs: oral oestrogen-containing contraception, heparin-induced thrombocytopenia

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