. Developmental and inherited disorders affecting the liver typically present in childhood but may affect individuals of any age. The effect of inherited metabolic disorders on the liver may be considered primary , caused by the accumulation of a metabolite…
CHAPTER CONTENTS Liver biopsy 96 Evolving role 96 Different types 97 Limitations of and requirements forinterpretation 99 Competitors and alternatives to liver biopsy 100 Routine handling, fixation and staining of liver specimens 103 Handling and fixation 103 Staining 104 Immunohistochemistry…
. The practice of hepatopathology requires a clear understanding of liver anatomy and physiology, as a prelude to understanding the expression of pathological processes in the liver. As an anatomical entity, the liver is deceptively simple. It is large, representing…
Quality assurance of intraoperative consultation (IOC) is typically part of a larger quality assurance (QA) plan for anatomic pathology or surgical pathology (Nakhleh and Fitzgibbons, 2005; Lester, 2006). Even though IOC is an integral part of surgical pathology, in most…
Infrastructure for Biospecimen Collection Intraoperative Consultation as A Site for Collection In this chapter we evaluate opportunities for the collection of biospecimens during intraoperative consultation (IOC). Because the majority of consultations occur in the context of cancer surgeries, we will…
Tumors of bone and soft tissue invariably require clinical history and radiologic evaluation for definitive diagnosis. Increasingly, core needle biopsy (CNB) is the primary method for obtaining tissue for diagnosis due to advancement of intraprocedural imaging techniques, safety, and cost…
Introduction Frozen section performance in the transplant setting is dominated by evaluation of donor organs to assess suitability for transplantation. Knowledge regarding certain clinical aspects of the donor is valuable, and this will be addressed first. We will then focus…
In this chapter we review a practical approach to intraoperative frozen section and highlight the role of the pathologist in guiding intraoperative decision making. For convenience sake, we use the term “frozen section,” but at the onset we wish to…
Pelvic lesions are submitted for frozen-section intraoperative determination of the nature of an ovarian, fallopian tube, or peritoneal mass or lesion. Those frozen sections usually have very important implication for management because most are submitted for evaluation with clinical suspicion…
Intraoperative and frozen section analyses are relatively uncommon for genitourologic surgery with about 5.4% of all urologist-generated specimens at our institution being submitted for intraoperative consultation (IOC). General indications include: 1) evaluation of resection margins, 2) diagnosis or classification of…