Summary of Key Points Pancreatic adenocarcinoma is the fourth leading cause of cancer-related death. The overall 5-year survival rate for all patients is less than 5%: 15% to 20% of patients present with resectable or borderline resectable disease with a…
Summary of Key Points Liver Cancer There is a continued rise of hepatocellular carcinoma (HCC) incidence, especially in the Western hemisphere. HCC main risk factors are hepatitis B, hepatitis C, alcohol use, and nonalcoholic steatohepatitis. Screening programs continue to evolve…
Summary of Key Points Incidence It was estimated that there were 8580 anal squamous cell carcinomas diagnosed and 1160 deaths from this disease in the United States in 2018. The age-adjusted incidence rate is 1.7 per 100,000 men and women…
Summary of Key Points Incidence Approximately 43,030 cases of rectal cancer will be diagnosed in the United States in 2018. The lifetime risk of developing colorectal cancer is roughly 4.5%. Higher rates of rectal cancer are noted in industrialized nations.…
Summary of Key Points Epidemiology Colorectal cancer (CRC) is the second most common cancer in women and the third most common cancer in men worldwide. Within economically developed countries, the lifetime risk of developing CRC varies among countries; for instance,…
Summary of Key Points Incidence Small bowel tumors are rare, with an incidence of less than 10% of new gastrointestinal (GI) cancer diagnoses and less than 1% of all newly diagnosed cancers each year. Genes involved include APC, KIT, and…
Summary of Key Points Epidemiology and Pathology In the United States, it was predicted that there would be 28,000 patients diagnosed with gastric cancer in 2017, with an estimated 10,960 deaths. In the United States, the site of origin is…
Summary of Key Points Classification Adenocarcinomas and squamous cell carcinomas (SCCs) comprise 98% of esophageal tumors. The Siewert classification is now commonly used to categorize gastroesophageal junction (GEJ) tumors, although many studies, especially those for advanced disease, have enrolled patients…
Summary of Key Points Malignant Pleural Mesothelioma Malignant pleural mesothelioma (MPM) is a rare disease with 2000 to 3000 cases occurring annually in the United States. Approximately 90% of the cases are attributed to prior asbestos exposure, with a latency…
Summary of Key Points Non–Small Cell Lung Cancer Non–small cell lung cancer (NSCLC) constitutes 80% to 85% of new cases of lung cancer in North America. The most frequent histologic types are adenocarcinoma, squamous cell carcinoma, and large cell carcinoma.…