See also Antiepileptic drugs General information Felbamate is a broad-spectrum antiepileptic drug, whose use has been drastically curtailed owing to the risks of aplastic anemia and hepatotoxicity. Benefit to harm balance The Quality Standards Subcommittee of the American Academy of…
General information Originally claimed, from animal experiments, to be of rapid onset, short duration, and free of important adverse effects and reactions, this non-depolarizing relaxant has been found to be less satisfactory in man. The usual doses are 0.5–0.75 mg/kg,…
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See also Histamine H 2 receptor antagonists General information Famotidine is a histamine H 2 receptor antagonist. It does not affect drug metabolism and it has been claimed to be free of the antiandrogenic effect of cimetidine; however in one…
General information Famciclovir is an oral prodrug of penciclovir, a selective antiviral drug with activity against Varicella zoster virus, Herpes simplex virus types 1 and 2, and Epstein–Barr virus, as well as human hepatitis B virus. After oral administration, famciclovir…
See also individual agents General information The direct inhibitors of factor Xa are short polysaccharides [ ]. They include rivaroxaban [BAY 59-7939; 5-chloro-N-(({(5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide)], apixaban, edoxaban, otamixaban, and DX-9065 [(+)-2S-2-[4-[[(3S)-1-acetimidoyl-3-pyrrolidinyl]oxy]phenyl]-3-(7-amidino-2-naphthyl) propanoic acid hydrochloride pentahydrate]. Direct inhibitors of factor Xa bind to…
See also Coagulation proteins General information Factor IX is used as substitution therapy in patients with hemophilia B. Although the half-lives of recombinant and plasma factor IX products are comparable, the in vivo recovery of recombinant factor IX is 28%…
See also Coagulation proteins General information Lyophilized factor VIII has been used as substitution therapy in patients with hemophilia A. Most, but not all, recombinant factor VIII (recFVIII) is structurally and immunologically similar to plasma-derived factor VIII, and it has…
See also Coagulation proteins General information Factor VII is the most sensitive of the vitamin K-dependent clotting factors. The mode of action is tissue factor-dependent activation of factors Xa and IXa on the surfaces of activated platelets [ ]. Factor…
General information The genera in the family of Fabaceae ( Table 1 ; formerly Leguminosae) include broom, licorice, senna, tamarind, and a variety of pulses, such as fava beans, lentil, peas, and vetches. Table 1 Genera of Fabaceae Abrus (abrus)…