See also Benzodiazepines General information Flunitrazepam has acquired a reputation for toxicity, abuse potential [ ] and associated forensic problems [ ], including being implicated in sexual assault (“date rape”) [ ]. It has been withdrawn from general availability in…
General information Flumazenil is used as a benzodiazepine antagonist in the treatment of poisoning or the reversal of benzodiazepine effects in anesthesia [ , ] or in neonates [ ]. Guidelines for its use have been summarized [ ]. The…
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See also Cytotoxic and immunosuppressant drugs General information Fludarabine phosphate is a purine nucleoside antitumor agent, which inhibits adenosine deaminase. It is mainly used to treat chronic lymphocytic leukemia. Dose-limiting myelotoxicity, nausea and vomiting, and raised liver enzymes were observed…
See also Cytotoxic and immunosuppressant drugs General information Flucytosine is an antimetabolite of the fluoropyrimidine type. The principle of selectivity of flucytosine for the fungal cell is dual: it depends on an enzyme in order to penetrate the cell (fungal…
See also Antifungal azoles [for systemic use] General information Fluconazole is an antifungal triazole that was derived from the older imidazoles. It has a lower molecular weight and is soluble in water. It can be administered orally and parenterally. Pharmacokinetics…
See also Cytotoxic and immunosuppressant drugs General information Floxuridine is a pyrimidine analogue that is used in regional arterial chemotherapy for primary and metastatic malignancies, delivered using an implantable pump. You’re Reading a Preview Become a Clinical Tree membership for…
See also COX-2 inhibitors (coxibs) General information The clinical development flosulide, a COX-2 inhibitor, was discontinued because of nephrotoxicity [ ]. Measurement of renal prostaglandin synthesis did not predict its nephrotoxicity in single-dose and short-term studies [ ]. You’re Reading…
See also Non-steroidal anti-inflammatory drugs (NSAIDs) General information Floctafenine is a 4-aminoquinoline NSAID, closely related to antrafenine and glafenine, and its adverse reactions profile is similar [ ]. Organs and systems You’re Reading a Preview Become a Clinical Tree membership…
See also Antidysrhythmic drugs General information Flecainide is a class Ic antidysrhythmic drug. Its clinical pharmacology, clinical use, and adverse effects and reactions have been reviewed [ ]. Drug studies Observational studies Intravenous flecainide 2 mg/kg over 10 minutes (maximum…