Introduction Hidradenitis suppurativa (HS) is a disabling chronic inflammatory disease with significant comorbidities that affects an estimated 1% of the Western population. A poor understanding of HS biology has limited the development of uniformly effective treatments. The characteristic lesions of…
Introduction The pathogenic model of hidradenitis suppurativa (HS) may be in the midst of a paradigm shift, balancing the initial model of a disorder of (primary) follicular occlusion with consideration as an autoinflammatory keratinization disease (AiKD). There is observational, experimental,…
Introduction Over time, repeated episodes of hidradenitis suppurativa (HS) disease flares can lead to a number of debilitating cutaneous, systemic, as well as psychological and social complications. Given the progressive course of this disease, early diagnosis and initiation of appropriate…
Introduction HS represents a prime candidate to bridge diseases of the integument and comorbid systemic disease, as a chronic inflammatory disease of the pilosebaceous unit characterized by inflammatory nodules, suppuration and abscess formation resulting in pain and disfigurement. In addition…
Overview of Patient Population with HS Prior to Initiating Therapy Hidradenitis suppurativa is a clinical diagnosis based on history, physical exams, patterns of recurrence, types of lesions, and scarring. No diagnostic test is currently available and biopsy results are relatively…
Introduction The imaging support of hidradenitis suppurativa (HS) has been increasing in the last decade due to the development of high-axial-resolution devices that can detect simultaneously and with high definition abnormalities of the skin and deeper layers. Nowadays, the spatial…
Introduction It is useful to consider the histological findings of hidradenitis suppurativa (HS) lesions in the context of populations at risk for HS to understand the clinical differences observed amongst these populations. HS disproportionately affects women, persons 18 to 29…
Introduction The average length of time from onset to diagnosis in hidradenitis suppurativa (HS) patients worldwide is 7.2 years. This unfortunate delay is partly because of the nonspecific nature of many HS lesions—inflammatory papules, nodules, pustules, abscesses, and scarring—which may…
Clinical Manifestation Morphology of Hidradenitis Suppurativa Lesions A key component of the diagnosis of an individual with hidradenitis suppurativa (HS) involves examining for the presence of typical HS morphology. The quantity and location of lesions indicate the severity of HS.…
Introduction This chapter will focus on the epidemiology of hidradenitis suppurativa (HS), examining the body of evidence available for estimating the incidence and prevalence of HS, and the distribution of HS by gender, age, and race. Epidemiology is a broad…