Risk Incidence in live births: 1:100,000-120,000 Affects equally males and females of all ethnic groups NP-D type A frequent in the Ashkenazi-Jewish population No curative therapy, although several symptomatic manifestations are treatable Associated with a decrease in life expectancy, although…
Risk Incidence of 0.01–0.02% Mortality rate of 10% 2000 cases of NMS diagnosed annually in USA hospitals Pharmacologic: Typical/“first generation” antipsychotic Rapid dose titration/switching agents/abrupt medication withdrawal/high cumulative dose IM depot/IV administration Multiple concurrent antipsychotics or antipsychotic with lithium/carbamazepine Demographic/miscellaneous:…
Risk NF-1 birth incidence: 1:3000 NF-2 birth incidence: 1:25,000 Schwannomatosis incidence: 1:40,000 Perioperative Risks Depend on tumor extent and location Worry About Difficult intubation Intraop Htn Intraop tachycardia Overview NF-1, formerly known as von Recklinghausen disease, is a relatively common,…
Risk Incidence: Reported in 8–44% of pts following bilateral adrenalectomy for Cushing disease More likely in pts with younger age and pregnancy Perioperative Risks Lyte imbalances DI Vision loss Challenges specific to type of surgery Worry About Panhypopituitarism Volume status…
Risk Incidence in USA: Approximately 9–11.5 cases of invasive streptococcal infections, from which 1–1.8 die each year STSS and NF, each comprising an average of 6–7% of these invasive cases, with an associated mortality of 35–50% for STSS and 29%…
Risk Most common life-threatening intestinal surgical emergency in the newborn. Occurs predominantly in premature infants, with 75% in infants weighing <1500 g. Increasing incidence in term and near-term neonates as well. Perioperative Risks CV instability, acidosis, shock, bowel ischemia, bacteremia,…
Risk Prevalence approximately 1:2000 Women and men equally affected Prevalence higher in Japan (1:600) Perioperative Risks Potential for masking or mimicking periop complications Potential deleterious interactions between drugs for narcolepsy and drugs administered periop Worry About There is little evidence…
Risk Although primary cardiac tumors are rare (<0.01%), myxoma is the most common type (50%). 75% develop in LA, with most attached to the interatrial septum. Rarely develop in ventricles. More common in females (70%). Perioperative Risks May be friable…
Risk Incidence of approximately 1:8000. Incidence of the congenital form is higher, with an incidence of 1:100,000 compared with adult-onset form. Perioperative Risks Operative/anesthetic and postop morbidity and mortality are increased and not proportional to severity of disease. High incidence…
Risk Prevalence: 1:400,000 Maternal inheritance; less commonly a spontaneous mitochondrial gene mutation in those without family Hx Perioperative Risks Lactic acidosis Cardiac/respiratory insufficiency/failure Delayed emergence Worry About Respiratory failure following sedation. Consider aspiration risk. Lactic acidosis. Seizures. Overview Mitochondrial myopathy…