See also Vaccines General information Influenza vaccine viruses are propagated in embryonated chicken eggs. The virus-containing extra-embryonic fluid is harvested, purified, and inactivated with formalin. Inactivated flu vaccine is produced either as whole virus vaccine or ether-disrupted split or subunit…
See also Monoclonal antibodies General information Infliximab is a chimeric, human-murine anti-TNF monoclonal antibody. It was initially approved by the Food and Drug and Administration in August 1998 for the treatment of moderately to severely active Crohn’s disease [ ,…
See also Alpha-adrenoceptor antagonists General information Indoramin is a postsynaptic selective alpha 1 -adrenoceptor antagonist that is chemically distinct from the quinazolines. Unlike some other alpha-blockers, indoramin lowers blood pressure without a resulting reflex tachycardia or postural hypotension [ ].…
See also Non-steroidal anti-inflammatory drugs (NSAIDs) General information Indoprofen is one of several NSAIDs that have been withdrawn because of adverse reactions. The UK Licensing Authority suspended the product licence on grounds of safety in 1983, and in 1984 the…
See also Non-steroidal anti-inflammatory drugs (NSAIDs) General information Indometacin is the best-known and most thoroughly tested indoleacetic acid derivative. It is one of the most effective non-steroidal anti-inflammatory drugs (NSAIDs), and most of its toxic and therapeutic effects appear to…
See also HIV protease inhibitors General information Indinavir is an HIV protease inhibitor. As for most other protease inhibitors, the use of indinavir has been markedly simplified by co-administration of low-dose ritonavir, which allows indinavir to be given twice daily…
General information Indapamide is a thiazide-like diuretic. Although it was introduced as a specific antihypertensive drug without appreciable diuretic action, the effects of indapamide are no different from those of bendroflumethiazide. Organs and systems Cardiovascular Indapamide has been associated with…
General information Indanediones have the same mechanism of action as the coumarins. However, they are generally more toxic than the coumarins, and can cause allergic reactions capable of involving many organs and sometimes resulting in death [ ]. These reactions…
See also Antivenoms , Hymenoptera venoms General information Desensitization is used in the treatment of IgE-mediated disease. Increasing doses of an allergen are injected subcutaneously over a varying time span. The aim of the treatment is to decrease sensitivity to…
General information Immunoglobulin preparations are concentrated protein solutions derived from pooled plasma from adults or animals. They contain specific antibodies in proportion to the infectious and immunization experience of the population from whose plasma they are prepared [ ]. Large…