General information Imiquimod is an immune response enhancer that induces production of interferon and several other cytokines. It is used, in formulations containing 5%, to treat external genital and perianal warts/condylomata acuminata in adults [ ]. As imiquimod-treated warts regress,…
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See also Angiotensin-converting enzyme inhibitors General information Imidapril is a long-acting, non-sulfhydryl ACE inhibitor that has been used in patients with hypertension, congestive heart failure, acute myocardial infarction, and diabetic nephropathy. It is a prodrug, rapidly converted in the liver…
General information Imatinib (STI571), an inhibitor of bcr-abl tyrosine kinase, has become the first-line agent in the treatment of the chronic phase of chronic myeloid leukemia and of locally advanced and metastatic gastrointestinal stromal tumors (GISTs) that express the CD117…
General information Iloprost is an analogue of prostacyclin (PGI 2 ), the pharmacodynamic properties of which it mimics, namely inhibition of platelet aggregation, vasodilatation, and cytoprotection. Iloprost has greater chemical stability than prostacyclin, which facilitates its clinical use [ ].…
General information The family of Illiciaceae contains a single genus, Illicium , the star anise species. Illicium species Illicium anisatum contains sesquiterpenoids, such as anisatin, anisotin, neoanisatin, and pseudoanisatin. Illicium religiosum (Japanese star anise) contains shikimic acid, anisatin and neoanisatin.…
See also Cytotoxic and immunosuppressant drugs General information Ifosfamide is an alkylating agent belonging to the group of oxazaphosphorines. It is used to treat a variety of solid tumors in children, including rhabdomyosarcoma, soft tissue sarcomas, Wilms’ tumor, bone sarcomas,…
General information Idoxuridine, which is active against Herpes simplex and Varicella zoster , has only been used in topical antiherpetic solutions. It has been used to treat superficial keratitis, but with poor results in deep stromal diseases because of poor…
General information Like tamoxifen, toremifene, and droloxifene, idoxifene is a polyphenylethylene antiestrogen. It is a selective estrogen receptor modulator (SERM) with greater antiestrogenic activity than tamoxifen but less estrogenic activity. Its preclinical toxicology has been reviewed [ ]. You’re Reading…
See also Non-steroidal anti-inflammatory drugs (NSAIDs) GENERAL INFORMATION Ibuproxam (2-(4-isobutylphenyl)-propiohydroxamic acid) is a derivative of ibuprofen (2-(4-isobutylphenyl)-propionic acid), and after absorption is gradually hydrolysed to ibuprofen [ ]. It is supposed to be less gastrotoxic than ibuprofen. However, gastrointestinal adverse…