See also Calcium channel blockers General information Amlodipine is a long-acting dihydropyridine calcium channel blocker. It has an adverse effects profile similar to those of other dihydropyridines, but at a lower frequency [ ]. Along with felodipine [ ], but…
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See also Neuroleptic drugs General information Amisulpride is an atypical antipsychotic drug, a benzamide derivative, which may have a low propensity to cause extrapyramidal symptoms [ ]. Amisulpride 600–1200 mg/day for 3 months was effective and well tolerated in 445…
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See also Antidysrhythmic drugs General information Amiodarone is highly effective in treating both ventricular and supraventricular dysrhythmias [ ]. Its pharmacology, therapeutic uses, and adverse effects and interactions have been extensively reviewed [ ]. General adverse effects and reactions Amiodarone…
General information The aminosalicylates that are currently available are: mesalazine (5-aminosalicylic; acid mesalamine); sulfasalazine, a compound of mesalazine and sulfapyridine, the two compounds being linked by a diazo bond that is hydrolysed by intestinal bacteria; mesalazine is therapeutically effective in…
See also Anorectic drugs General information Aminorex is an amfetamine analogue that was used as an anorectic agent, but was withdrawn from the market over 20 years ago because of its association with pulmonary hypertension, which sometimes proved fatal. Its…
General information Aminophenazone (amidopyrine) is the most toxic and most dangerous anti-inflammatory analgesic. Blood dyscrasias have been documented beyond any doubt, perhaps due to a hypersensitivity mechanism. The Committee on the Safety of Drugs of the Japanese Pharmaceutical Affairs Bureau…
General information Aminolevulinic acid (5-aminolevulinic acid, δ-aminolevulinic acid, 5ALA, δ-ALA) is the first compound in the porphyrin synthesis pathway, which leads to heme in mammals and chlorophyll in plants. It has been used as a component of photodynamic therapy in…
See also individual agents General information The aminoglycosides that have been, or are still, important in medical practice are amikacin, gentamicin (pINN), isepamicin, kanamycin, neomycin, netilmicin, paromomycin, sisomicin, streptomycin and dihydrostreptomycin, and tobramycin. Being chemically similar, the aminoglycosides have many…