Uropathology

Genital melanosis and lentiginosis

Definition Benign hyperpigmented lesions in the external genitalia area (e.g., glans and foreskin) Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in…

Idiopathic scrotal calcinosis

Definition Calcification of dermal connective tissue of the scrotal skin Clinical features Epidemiology Usually occurs in young men, with children and older men reportedly also being affected. You’re Reading a Preview Become a Clinical Tree membership for Full access and…

Sclerosing lipogranuloma

Definition Granulomatous tissue reaction typically following the injection of exogenous lipid-rich substance in the male genitalia (penis, scrotum, testis, perineum, or spermatic cord) Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited…

Merkel cell carcinoma of the genitourinary tract

Definition Aggressive neoplasm of neuroendocrine differentiation, identical to its cutaneous counterpart Clinical features Epidemiology Primary Merkel cell carcinoma of the genitourinary (GU) tract extremely rare, with single case reports in the vulva, vagina, penis, and scrotum Patient age between third…

Extramammary Paget disease of the penis and scrotum

Definition Rare intraepidermal adenocarcinoma involving the skin or mucosa of the external genitalia Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in…

Penile basal cell carcinoma

Definition A rare indolent neoplasm of the penis identical to its cutaneous counterpart Clinical features Epidemiology Very rare, only less than 50 cases reported even when scrotal tumors are included Age range: 37–87 (usually above 40) White men mostly Etiology…

Mixed squamous cell carcinoma of the penis

Definition Squamous cell carcinoma (SCC) showing morphologic features of more than one histologic subtype in the same specimen Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you…

Adenosquamous carcinoma of the penis

Definition A form of penile squamous cell carcinoma (SCC) with both squamous and adenocarcinomatous components, probably arising from the embryologically misplaced glands or metaplastic mucinous glands Clinical features Epidemiology Non-HPV related Rare Similar to usual SCC You’re Reading a Preview…

Sarcomatoid (spindle cell) squamous cell carcinoma of the penis

Definition Squamous cell carcinoma with a malignant spindle cell or heterologous sarcomatoid component Clinical features Usually manifests as a white-gray, mixed exophytic and endophytic mass on the glans penis You’re Reading a Preview Become a Clinical Tree membership for Full…

Squamous cell carcinoma, cuniculatum

Definition A variant of verrucous carcinoma corresponding to a low-grade verruciform squamous cell carcinoma characterized by deeply infiltrating and interconnected tumor nests forming a burrowing pattern Clinical features Epidemiology Rare, with only a few bona fide cases reported Not related…