Uropathology

Malignant nephrosclerosis

Definition A clinicopathological syndrome characterized by a thrombotic microangiopathy induced by severe hypertension (systolic pressure greater than 220 mm Hg or diastolic pressure greater than 120 mm Hg) Clinical features Epidemiology The average age at diagnosis is 40 years, and…

Benign nephrosclerosis

Definition Pathological changes in the kidney induced by chronic mild to moderate hypertension Clinical features Epidemiology Hypertension affects 20%–40% of the population in Western society. Vascular diseases of the kidneys can be both a cause and a consequence of hypertension.…

Renal papillary necrosis

Definition Coagulative necrosis involving the papillae of the renal medulla, classically associated with a number of underlying conditions, all of which predispose the patient to renal medullary ischemia Clinical features You’re Reading a Preview Become a Clinical Tree membership for…

Xanthogranulomatous pyelonephritis

Definition A destructive granulomatous inflammatory process of renal parenchyma as the result of long-term urinary tract obstruction and infection Clinical features Epidemiology Seventy percent of patients are female. Ages range widely, from newborn to elderly. Urine cultures most frequently show…

Chronic obstructive pyelonephritis

Definition Pathologic changes secondary to chronic obstruction of the urinary outflow Clinical features Epidemiology Obstruction is more common in males during childhood (ureteropelvic obstruction, posterior urethral valves, and other congenital anomalies), in females during adulthood (gynecologic diseases), and in males…

Chronic nonobstructive pyelonephritis

Definition Pathological changes observed in the kidney as the result of vesicoureteral reflux (VUR), intrarenal reflux, and repeated UTIs; also termed reflux nephropathy Clinical features Epidemiology VUR occurs in approximately 1% of children and is found in 30%–50% of children…

Acute pyelonephritis

Definition Acute suppurative inflammation of the kidney caused by bacterial infection, due most commonly to ascent from a lower urinary tract infection and less commonly to hematogenous spread in septic patients Clinical features Epidemiology Common, with 15–17 cases annually per…

Simple cortical cyst

Definition An acquired cystic lesion with fluid collection in the kidney; may originate from diverticula of the distal renal tubules or collecting ducts. Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited…

Acquired cystic renal disease

Definition Development of bilateral and multiple renal cysts in patients whose chronic renal failure cannot be attributed to a hereditary etiology Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become…

Medullary sponge kidney

Definition Cystic dilatation of papillary collecting ducts of one or more renal pyramids Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in…