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See also Macrolide antibiotics General information Adverse reactions to dirithromycin were studied in 4263 patients [ ]. There was abdominal pain in 5.6%, diarrhea in 5.0%, and nausea in 4.9%. Headache was relatively common (4.5%). In 63% of cases the…
General information Dipyridamole inhibits platelet aggregation by inhibiting platelet cyclic AMP phosphodiesterase, potentiating adenosine inhibition of platelet function by blocking adenosine reuptake by vascular and blood cells and breakdown of adenosine, and by potentiating prostaglandin I 2 antiaggregatory activity and…
See also Vaccines ; Pertussis vaccines General information Diphtheria vaccine contains diphtheria toxoid carried on aluminium hydroxide or calcium phosphate. Single antigen products are available only for cases in which combined antigens should not be used. The formulations used in…
See also Antihistamines General information Diphenylpyraline is an antihistamine, a piperidine derivative [ ], with antimuscarinic and sedative properties. It has been used to treat allergic and vasomotor rhinitis [ ], chronic urticaria [ ], and the symptoms of the…
General information Diphenoxylate is a synthetic compound designed to have the antidiarrheal effects of the opiates, but it also retains some less desirable opiate effects. It is generally combined with atropine, as co-phenotrope, which was originally added to the formulation…
See also Antihistamines General information Diphenhydramine is a typically sedating first-generation antihistamine. It is still widely used, mainly in over-the-counter products, often in combination with other drugs. Diphenhydramine inhibits CYP2D6 and can cause clinically important interactions with many CYP2D6 substrates,…
General information Diphencyprone (diphenylcyclopropenone) is a potent sensitizing chemical used to induce a contact dermatitis of the scalp in the topical immunotherapy of alopecia areata [ ] and warts [ ]. Drug studies You’re Reading a Preview Become a Clinical…
See also individual agents General information Sitagliptin ([2R]-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo(4,3-a)pyrazin-7(8H)-yl]-1-[2,4,5-trifluorophenyl]butan-2-amine) [ ] was the first inhibitor of dipeptidyl peptidase type 4 (DPP-4) to have received a licence in the UK (in 2007). Other are linagliptin, saxagliptin, and vildagliptin. DPP-4 is an enzyme…
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