General information Dopexamine, which is related structurally to dopamine, is a potent β 2 -adrenoceptor agonist and dopamine D 1 receptor agonist, which is a vasodilator at low doses, with beneficial effects on splanchnic blood flow, and a vasconstrictor at…
General information Dopamine is a naturally occurring catecholamine and central neurotransmitter capable of raising cardiac output, reducing peripheral resistance, and specifically increasing renal blood flow. Infusions (generally up to 10 micrograms/kg/hour) have proven valuable in shock and congestive heart failure.…
General information The approval of donepezil in several countries in America and Europe has been hailed as a major milestone, because it has met regulatory guidelines for the approval of anti-dementia drugs [ ]. Donepezil belongs to a piperidine class…
General information Domperidone is a neuroleptic antiemetic, a dopamine receptor antagonist. It produces the expected range of dystonic and extrapyramidal adverse effects [ ], which seem, as with metoclopramide, to be more likely to occur in children [ ]. It…
General information Dofetilide is a pure Class III antidysrhythmic drug, without actions of any other class. It was developed following the observation that bis(arylalkyl)amines with methanesulfonamido moieties on both aryl groups prolong the cardiac action potential without significantly altering the…
See also Cytotoxic and immunosuppressant drugs General information Docetaxel is a taxane that is used in combination with doxorubicin in the treatment of metastatic breast cancer and as a single agent in metastatic lung cancer. Organs and systems Respiratory Interstitial…
General information Dobutamine is a relatively selective β 1 -adrenoceptor agonist with only slight β 2 – and α-adrenoceptor activity. It has been developed as a positive inotropic agent that is less vasoconstrictive than high doses of dopamine. Organs and…
General information Diuretics are among the most widely used drugs, particularly for the treatment of hypertension and of various conditions associated with sodium retention. Considering the widespread use of diuretics over a long period (chlorothiazide was introduced in 1957) their…
See also Diethyldithiocarbamate General information Oxidation of sodium diethyldithiocarbamate gives a disulfide, also called thiuram disulfide or disulfiram. Disulfiram has been widely used since the late 1940s to facilitate abstinence from alcohol [ ]. Concomitant use of alcohol during disulfiram…
See also Antidysrhythmic drugs General information The use, clinical pharmacology, and adverse effects of disopyramide have been reviewed [ , ]. Drug studies Observational studies Because of its negative inotropic effect, disopyramide reduces the left ventricular outflow gradient and improves…