See also Antihistamines General information Fexofenadine is the active metabolite of terfenadine. It has antihistaminic but not dysrhythmogenic properties. It is not metabolized by the liver, but eliminated unchanged in the urine. It is efficacious and well tolerated in seasonal…
See also Non-steroidal anti-inflammatory drugs (NSAIDs) General information Feprazone is an NSAID that is related to phenylbutazone. It was withdrawn in the UK because of adverse reactions, which resemble those of phenylbutazone. It was designated as a last-resort drug by…
See also Non-steroidal anti-inflammatory drugs (NSAIDs) General information Fentiazac, a thiazoleacetic acid derivative, has the same adverse reactions profile as other NSAIDs. Adverse reactions in as many as 56% of patients (5–56%), are even more frequent than with phenylbutazone […
See also Opioid receptor agonists . General information Fentanyl citrate is a synthetic opioid 1000 times more potent than pethidine. It has a relatively short duration of action, and its effects are rapidly reversed by opioid antagonists [ ]. It…
General information Fenspiride is a bronchodilator and anti-inflammatory drug. Two in vitro studies have suggested possible mechanisms for these effects. Functional studies in human isolated bronchi showed that fenspiride causes a shift to the left of concentration effect curves for…
See also Amphetamines , Anorectic drugs General information Fenproporex is structurally related to amfetamine, to which it is rapidly metabolized after oral ingestion. Stimulatory effects, somnolence, and electroencephalographic abnormalities are reported to be the major undesired reactions [ ]. Dependence…
See also Beta 2 -adrenoceptor agonists General information Fenoterol is a β 2 -adrenoceptor agonist with higher intrinsic activity than salbutamol; it produces a greater maximal effect and has greater systemic effects at higher than conventional doses. It is available…
General information Fenoldopam is a selective dopamine D 1 receptor agonist, which has been used in the management of acute severe hypertension and heart failure [ ], and to preserve renal function in various circumstances, such as after cardiac surgery…
See also Anorectic drugs ; Benfluorex ; Phentermine General information Although it resembles amfetamine structurally, the appetite suppressant fenfluramine does not produce central nervous system stimulation in therapeutic doses. Dexfenfluramine, the dextrorotatory isomer, was previously widely marketed as an appetite…
See also Non-steroidal anti-inflammatory drugs (NSAIDs) General information Fenclofenac was withdrawn in the UK after its licence was not renewed because of its adverse drug reactions profile [ ]. Data from the UK's Committee on Safety of Medicines included records…