See also Coagulation proteins General information Factor IX is used as substitution therapy in patients with hemophilia B. Although the half-lives of recombinant and plasma factor IX products are comparable, the in vivo recovery of recombinant factor IX is 28%…
See also Coagulation proteins General information Lyophilized factor VIII has been used as substitution therapy in patients with hemophilia A. Most, but not all, recombinant factor VIII (recFVIII) is structurally and immunologically similar to plasma-derived factor VIII, and it has…
See also Coagulation proteins General information Factor VII is the most sensitive of the vitamin K-dependent clotting factors. The mode of action is tissue factor-dependent activation of factors Xa and IXa on the surfaces of activated platelets [ ]. Factor…
General information The genera in the family of Fabaceae ( Table 1 ; formerly Leguminosae) include broom, licorice, senna, tamarind, and a variety of pulses, such as fava beans, lentil, peas, and vetches. Table 1 Genera of Fabaceae Abrus (abrus)…
General information Ezetimibe is a selective potent inhibitor of the intestinal absorption of dietary and biliary cholesterol. A total of 432 patients were included in a pooled analysis of two phase-II studies, both lasting for 12 weeks; ezetimibe was well…
General information Eyedrops and ointments are specialized pharmaceutical formulations intended to produce therapeutic concentrations of the active drug in ocular structures; a lower dose can be used than would be necessary to obtain the same effect by systemic administration. They…
General information Exenatide (synthetic exendin-4, from the saliva from a lizard) is an incretin mimetic [ ]. Incretins are compounds that increase insulin secretion from the pancreas in a glucose-dependent manner; they are therefore potential therapies for the treatment of…
General information Everolimus is an immunosuppressive macrolide that also has synergistic actions with ciclosporin and interrupts the proliferative responses of vascular and bronchial smooth muscle cells. In a phase I trial, its safety profile and pharmacokinetics were assessed during a…
General information The genera in the family of Euphorbiaceae ( Table 1 ) include various spurges, such as poinsettia and croton. Table 1 Genera of Euphorbiaceae Acalypha (copperleaf) Croton (croton) Mercurialis (mercurialis) Adelia (wild lime) Dalechampia (dalechampia) Pedilanthus (pedilanthus) Alchornea…
General information Etomidate, a non-barbiturate anesthetic, is considered to be safe, especially in patients with hemodynamic instability. The most common complications of using etomidate are venous sequelae, pain on injection [ ], and involuntary muscle movements [ ]. Organs and…