Essence of Anesthesia Practice

Gastroesophageal Reflux in Children

Risk Physiologic GER usually resolves by 12–15 mo of age. 10% of pyloric stenosis pts. After diaphragmatic hernia, tracheoesophageal fistula, and esophageal atresia repairs Neurologically impaired, developmentally delayed, trisomy syndromes, and hiatal hernia. Perioperative Risks Aspiration during induction of anesthesia…

Gastrinoma

Acknowledgment The authors would like to acknowledge Dr. Christine Piefer’s contribution to this text in the previous edition. Risk Occurs in about 0.1–3 cases per million, usually in pts aged 20–50 y; male/female predominance about equal. 65–80% of gastrinomas are…

Galactosemia

Risk Rare autosomal recessive metabolic disorder that can present increased anesthesia risks. Inherited disease of carbohydrate metabolism affecting how the body processes the simple sugar galactose. The primary risk factor is having parents who carry the gene for galactosemia. Life-threatening…

Friedreich Ataxia

Risk Prevalence: 2:100,000; 80–90% have cardiac involvement. Worry About Cardiac involvement, which does not correlate with neurologic involvement. Electrophysiologic disturbances. Cardiac dysfunction and failure. Overview Progressive degeneration of posterior columns and corticospinal and posterior spinocerebellar tracts. Muscle weakness. General anesthesia…

Foreign Body Aspiration

Risk Most prevalent in children ages ≤3 y. In adults, elderly are most susceptible to FB aspiration. Risk factors include Alzheimer disease or dementia, stroke, loss of consciousness due to trauma, alcohol intoxication, or drug overdose. Foods are most commonly…

Fat Embolism

Risk Long bone fractures and pelvic fractures: 80–100% fat embolism Less than 1–30% FES Male-female ratio: 4:1 Adult greatly increased over pediatric Multiple fractures >single fractures Pathologic fractures >traumatic fractures Total hip, total knee replacement, intramedullary nailing: 27–100% fat embolism…

Fanconi Syndrome

Risk FS can be inherited, acquired, or caused by exogenous factors. Incidence is sporadic. Exact incidence in USA is not clear. Most diseases associated with FS are inherited in an autosomal recessive pattern. Cystinosis is the most common cause in…

Familial Periodic Paralysis

Risk Rare; hyperPP approximately 1:200,000 and hypoPP approximately 1:100,000 HyperPP with childhood onset; hypoPP with teenage onset Perioperative Risks In hyperPP, succinylcholine may provoke severe myotonia, provide no relaxation, and cause hyperkalemia (resulting postop muscle weakness over days and rhythm…

Familial Dysautonomia (Riley-Day Syndrome)

Risk Autosomal recessive transmission Complete penetrance, marked variability in expression Predominantly affects Ashkenazi Jewish population (incidence 1:10,000–20,000; carrier frequency 1:27-32) Perioperative Risks Intraop: Primarily cardiovascular with hemodynamic variability Postop: Primarily cyclic vomiting and pulmonary complications Worry About Paroxysmal dysautonomic crisis…

Factor V Leiden Mutation

Risk Most common hereditary thrombophilia Autosomal dominant inheritance pattern Heterozygous form in 5% of white population in USA (up to 15% in Europe), 2% of Hispanic Americans, 1% in both African and Native Americans Homozygosity in white population 1:5000 May…