Risk Incidence of hemophilia A, factor VIII (FVIII) deficiency is 1:5000 male births; for hemophilia B, factor IX (FIX, Christmas disease) deficiency, it is 1:25,000 male births. Number of people affected with hemophilia in USA is estimated at approximately 20,000.…
Risk Incidence of primary (hereditary) hemochromatosis: In some Caucasian populations, 10% are heterozygous carriers and 0.25–1% homozygous. Age: Clinical manifestations typically occur after age 40 in men and later in women due to the protective effect of menses. Perioperative Risks…
Risk Occurs in 0.1–0.9% of all pregnancies. Previous history of preeclampsia or HELLP syndrome is a risk factor for HELLP. Occurs in 10–20% of women suffering from preeclampsia with severe features. May be a form of preeclampsia. Preeclampsia occurs in…
Risk CHD is the most common birth defect. Incidence: 1:25 live births. 85–90% of pts with CHD survive to adulthood in USA due to advances in medical care. Perioperative Risks The highest risk factors of this complex disease include HLHS;…
Risk Incidence in USA: >28 million; maximum prevalence is in 25–55 y of age. Can start as early as 1 y of age; 10–20% of instances occur in children by 20 y of age, with males and females being equally…
Risk Hashimoto thyroiditis is the most common cause of hypothyroidism in iodine-sufficient countries and primary hypothyroidism in adults. Incidence in USA: Approximately 100,000–400,000 new cases diagnosed each year. Causes thyroid failure in 10% of pts. Prevalence increases with age but…
Risk Occurs in both sexes, all races, all ages, but mostly affects young and middle-aged adults. Worldwide illness and occurs at all times of the year. Mortality rate is 3–7%; most pts eventually fully recover and 20% have significant residual…
Risk Incidence: Approximately 5:10,000; prevalence: 1.12%, with 1.3 million pts in USA. Female-to-male ratio: 7:1; more common in women age 30–60 y. Family history indicating genetic factor(s) can be involved. Perioperative Risks “Thyroid storm” due to surge of plasma thyroid…
Risk Overall incidence: 0.05% in the USA population Most common inflammatory joint disease among men Associated with nephropathy, most commonly nephrolithiasis (10–40% of pts) Also associated with CV disease, specifically an increased risk of myocardial infarction, but also including heart…
Risk Incidence of 1 case per million people per y. Accounts for 20% of cases of RPGN or crescentic glomerulonephritis. In terms of bimodal age distribution, more common in males 20–30 y of age and females 60–70 y of age.…