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Adefovir
General information
Adefovir is an adenine analogue reverse transcriptase inhibitor. While it has activity against both HIV and hepatitis B, its use in HIV infection is limited by nephrotoxicity due to the high doses needed [ ]. The dose used for treatment of hepatitis B is about one-tenth that needed to treat HIV infection, so patients with hepatitis B must have co-infection with HIV ruled out before treatment is started.
Observational studies
A total of 49 consecutive lamivudine-resistant hepatitis B e antigen-negative chronic hepatitis B patients were enrolled in a study of the effects of adefovir 10 mg/day plus lamivudine 100 mg/day [ ]. After 52 weeks all had some hepatitis B virus DNA response and 57% had a complete virological response. There was a biochemical response in 76%. There were no serious adverse events.
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