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Differentiated penile intraepithelial neoplasia


Definition

  • Non-HPV-related premalignant precursor lesion of the penis characterized by cytologic atypia and abnormal epithelial maturation in the squamous epithelium lining the glans, coronal sulcus, or foreskin, with no extension beyond the basal lamina.

Clinical features

Epidemiology

  • Similar to invasive squamous cell carcinoma of the penis

  • Not associated with HPV infection

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