Subcorneal vesiculobullous disorders Pemphigus foliaceus Key Features Subcorneal split Acantholysis (loss of attachments between keratinocytes) Dyskeratosis may occur within the granular layer Direct immunofluorescence demonstrates “netlike” deposition of immunoglobulin (Ig) G and C3 between keratinocytes in upper epidermis Pemphigus foliaceus…
Evidence Levels: A Double-blind study B Clinical trial ≥ 20 subjects C Clinical trial < 20 subjects D Series ≥ 5 subjects E Anecdotal case reports Open full size image Human bed bugs ( Cimex lectularius ) are insects that…
1 List the functions of the nails Nails protect the terminal phalanx and fingertip from traumatic impact Nails help to perform tasks that require manual dexterity Nails, while unparalleled in their ability to relieve itching, cause trauma to the skin…
1 “Dermatologic emergencies” sounds like an oxymoron. Are there dermatologic emergencies? Yes, while perhaps not as ubiquitous as other areas of medicine, there are some dermatologic emergencies. In some of these emergent conditions, the skin is the primary organ affected…
1 A girl from southern India is anemic, and her school performance has declined. On examination, the child has dark, mascara-like makeup around her eyes. You suspect the makeup is the cause of these medical and social problems. What is…
1 What is “skin of color”? There are many ways to subcategorize humans. Widely recognized racial groups include Africans, African-Americans, Asians, Middle Easterners, Northern Europeans, Native Americans, Pacific Islanders, and Hispanics, to name a few. Even within a racial group,…
1 How common are skin disorders in elderly persons? Skin diseases appear more common in the geriatric population than the general population. This may be due to intrinsic skin aging and senescence, immune dysfunction, polypharmacy, and even cognitive and physical…
Key Points: Topical Steroids 1. Approximately 2% total body surface area (TBSA) requires one fingertip unit (FTU) or 0.5 g of topical steroid medication. One percent of the patient's TBSA can be estimated as one palmar surface, including the fingers.…
1 List some important facts about skin cancer About 90% of nonmelanoma skin cancers are related to ultraviolet (UV) radiation from the sun. More than 5.4 million cases of nonmelanoma skin cancer were treated in over 3.3 million people in…
1 How often do internal malignancies metastasize to the skin? Cutaneous metastases from internal malignancies are uncommon, with a reported incidence that varies from less than 1% to over 10%. The largest autopsy study including 7500 patients with internal malignancies…