Introduction This chapter is designed to be a broad overview of selected systemic therapies for dermatologic diseases. It provides an historical perspective for each drug, a discussion of its mechanism of action and side effects, and touches briefly on indications…
Key Points Systemic medications used for dermatologic conditions are associated with risks. The choice of systemic medication requires assessment of the disease severity and the performance of a risk–risk analysis balancing the risk of the disease with the risks of…
Questions Q68.1 What are some of the important medical benefits (for the patient) from a truly informed consent process? (Pg. 754) Q68.2 What are important differences between ‘express’ consent and ‘implied’ consent? (Pg. 754) Q68.3 What are some malpractice and…
Questions Q64.1 How can clinicians establish drug causation for all drug adverse effects, including the possibility of drug-induced malignancy? (Pg. 701) Q64.2 What are the pros and cons of using the s urveillance e pidemiology and e nd r esults…
Questions Q62.1 Concerning various categories of liver disease, what percentage of patients likely have drug causation: (1) adults with hepatitis, (2) adults with hepatitis at least 50-years-old, (3) all patients with fulminant hepatitis? (Pg. 678, Table 62.1 ) Q62.2 What…
Questions Q13.1 Concerning prednisone and cortisone, what is (1) the active form of each drug, (2) the enzyme necessary for this conversion, and (3) the effect of severe liver disease on this conversion? (Pgs. 134, 135) Q13.2 What are ‘physiologic…
Questions Q8.1 Concerning product labeling for a specific drug, (1) what are the four components of the ‘label,’ (2) what is the purpose of the label, and (3) what are ways that some flexibility is built into the process? (Pg.…
Questions Q5.1 Why is a uniform treatment approach for all patients with a given dermatosis inappropriate? ( Pg. 40 ) Q5.2 How do you communicate the uncertainty of a diagnosis or treatment plan to a patient? ( Pg. 41 )…
Questions Q2.1 What four words characterize the overall approach to maximizing drug safety, and what general concepts are represented by these words? (Pg. 12) Q2.2 How are the ‘standards of care’ for drug therapy monitoring determined? (Pg. 13) Q2.3 What…
Questions Q1.1 What are the simplest definitions of ‘pharmacokinetics’, ‘pharmacodynamics’, and ‘pharmacogenetics’? (Pg. 1, Table 1.1 ) Q1.2 What are several drugs or drug families for which the absorption may be altered by (1) food, (2) cations such as iron,…