Tag Lee A. Fleisher

Osteoporosis

Risk Most common metabolic bone disease in USA All elderly pts of European descent considered at risk Non-Hispanic white women and Asian women at highest risk Estimate is that over 200 million people worldwide are at risk. Approximately 30% of…

Noonan Syndrome

Risk Incidence between 1:1000-2500 live births Incidence consistent worldwide Equal distribution between genders Perioperative Risks Airway Cardiovascular Hematologic Infectious Worry About Difficult airway Cardiovascular complications Bleeding Endocarditis Overview Key features include facial anomalies, neck webbing, short stature, chest deformity, spinal…

Neuroleptic Malignant Syndrome

Risk Incidence of 0.01–0.02% Mortality rate of 10% 2000 cases of NMS diagnosed annually in USA hospitals Pharmacologic: Typical/“first generation” antipsychotic Rapid dose titration/switching agents/abrupt medication withdrawal/high cumulative dose IM depot/IV administration Multiple concurrent antipsychotics or antipsychotic with lithium/carbamazepine Demographic/miscellaneous:…

Myasthenia Gravis

Risk Prevalence of myasthenia gravis in USA is estimated at 14 to 20 per 100,000 population; there are approximately 36,000–60,000 cases in USA. Affects all races. Male:female ratio: 2:1. Perioperative Risks Postop NM ventilatory failure Postop pneumonia due to poor…

Long QT Syndrome

Risk Prevalence of cLQTS: Approximately 1:5000 live births. Incidence of cLQTS: 1 in 10,000. 60–70% of those diagnosed are females. Males under 10 y of age have the highest mortality. Pts usually present in childhood with a cardiac event. Perioperative…

Liddle Syndrome

Risk Extremely rare but described in a variety of populations True incidence and prevalence unknown Perioperative Risks Chronically untreated Htn Worry About Undiagnosed cerebrovascular, CV, and/or renal disease secondary to chronic Htn Worsening of hypokalemia with hyperventilation and nasogastric suctioning…

Klippel-Feil Syndrome

Risk Incidence estimated at 1:40,000 live births (but milder cases go unrecognized). Slight female predilection (63%). Perioperative Risks Cervical spine instability and cardiopulmonary complications. Often occurs in association with other clinical syndromes (e.g., fetal alcohol, Goldenhar). Worry About Exacerbation of…

Hypophosphatemia

Risk Incidence: 1% of population, 5–20% of hospitalized pts Perioperative Risks Acute respiratory or cardiac failure, generalized weakness, confusion, seizures You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you…

Hypertension

Risk In USA about 77.9 million (1:3) adults have high BP. Incidence of Htn increases with advancing age. Half of people 60–69 y and three-quarters of people >70 y are affected. There is a continuous relationship between BP and the…