Tag Lee A. Fleisher

Scleroderma

Risk Incidence: 9:1,000,000 per y. Prevalence: 300,000 Americans have scleroderma. Male:female ratio is 1:4; highest in young African-American women. More severe in Native Americans and African Americans. 10-y survival is 55–60%; presence of pulm Htn is a major prognostic predictor.…

Rheumatoid Arthritis

Risk Internationally the prevalence of RA is believed to range from 0.4% to 1.3%. In 2005, an estimated 1.5 million (0.6%) of USA adults >18 y had RA. Male-female ratio: 1:2. Perioperative Risks Risk of neurologic injury is increased due…

Reye Syndrome

Risk Incidence prior to 1990: 0.3–0.6:100,000. From 1987 to 1993: 0.03-0.06:100,000; 2 cases/y have been reported since 1994. During early 1980s, an association between aspirin and Reye syndrome was recognized; thereafter, incidence declined dramatically. In 1986, a warning label on…

Rett Syndrome

Risk Occurs almost exclusively in females. Incidence is 0.4–0.7:10,000. Perioperative Risks Abnormal control of ventilation, with periods of apnea and hyperventilation May have GE reflux Multiple orthopedic and motor movement disorders Worry About Risk of periop apnea not known Risk…

Renal Failure, Chronic

Risk Incidence in USA and worldwide: >100 cases of ESRD per million population. Between NHANES of 1988–1994 and that of 2003–2006, the prevalence of CKD in people 60 y and older jumped from 18.8% to 24.5%. Racial prevalence: African Americans,…

Pompe Disease

Risk Combined incidence (infantile vs. late-onset): 1:40,000. Infantile form has higher incidence in African-American and Chinese populations. Late-onset disease has a higher incidence in the Netherlands. Perioperative Risks Respiratory insufficiency Aspiration pneumonia Pulm edema Myocardial ischemia Worry About Respiratory insufficiency,…

Polymyositis

Risk Annual incidence in USA: 5.5:1,000,000, most prevalent among black women Annual incidence around the world: 1.9-7.7:1,000,000, although comprehensive epidemiologic data are lacking Perioperative Risks Delayed recovery from muscle relaxation Aspiration pneumonitis Cardiac arrhythmias CHF Worry About Increased risk of…

Papillomatosis

Risk Incidence of recurrent respiratory papillomatosis (RRP) in USA estimated at 4.3:100,000 among children and 1.8:100,000 among adults. Vertical transmission during delivery is believed to be the major mode of transmission for juvenile-onset recurrent respiratory papillomatosis (JORRP). Case reports show…

Paget Disease

Risk Second most common bone disorder after osteoporosis. Most common in individuals of Anglo-Saxon descent; men > women Prevalence increases with age and can be as high as 9–15% in people >80 y; average age at diagnosis in USA is…